乌司他丁改善肾综合出血热血管损伤的临床效果评价
发布时间：2018-08-01 10:32
【摘要】：目的:探究乌司他丁对改善肾综合出血热引起的毛细血管损伤而发生异常渗漏的临床治疗效果。方法:根据随机数字表将50例肾综合出血热的患者分为两组。给予实验组患者(25例)乌司他丁治疗;给予对照组(25例)5%糖溶液,作为空白对照。此外,根据实验组中患者就诊时发热时间分为两组。实验组A(9例)为发热1~4 d;实验组B(16例)为发热5~7 d。所有患者均在治疗后7 d后进行尿微量蛋白、血肌酐和血浆白蛋白等临床指标测定并对比。结果:与对照组相比,实验组尿微量蛋白下降显著;血肌酐恢复速度更快;血浆白蛋白上升明显;发生尿少症状的时间明显减少;并发症发生时间也明显减少;均P0.05,差异有统计学意义。与实验组B对比,实验组A尿微量蛋白下降显著;血肌酐恢复速度更快;血浆白蛋白上升明显;并发症发生时间也明显减少;均P0.05,差异存在统计学意义。结论:乌司他丁能有效治疗毛细血管渗漏综合征,并且在发热早期应用效果最佳。
[Abstract]:Aim: to investigate the clinical effect of ulinastatin on the treatment of abnormal leakage caused by renal complicated haemorrhagic fever. Methods: 50 patients with renal complicated hemorrhagic fever were randomly divided into two groups. The experimental group (25 cases) were treated with ulinastatin and the control group (25 cases) with 5% sugar solution as blank control. In addition, the patients in the experimental group were divided into two groups according to the time of fever. Group A (n = 9) had fever for 1 d and group B (n = 16) for 5 d. All patients were measured and compared with urinary microprotein, serum creatinine and plasma albumin 7 days after treatment. Results: compared with the control group, the urinary trace protein decreased significantly in the experimental group, the recovery rate of serum creatinine was faster, the plasma albumin increased significantly, the time of occurrence of urinary oligocytoma was significantly decreased, the time of complications was also decreased. The difference was statistically significant (P 0.05). Compared with the control group B, the urinary microalbuminuria of the experimental group A decreased significantly; the recovery rate of serum creatinine was faster; the plasma albumin increased significantly; the time of complications also decreased significantly; the difference was statistically significant (P 0.05). Conclusion: ulinastatin is effective in the treatment of capillary leakage syndrome, and is the best in the early stage of fever.
【作者单位】： 广州市第八人民医院急诊科;
【基金】：广州市科技计划项目(编号:201607010302)
【分类号】：R512.8
[Abstract]:Aim: to investigate the clinical effect of ulinastatin on the treatment of abnormal leakage caused by renal complicated haemorrhagic fever. Methods: 50 patients with renal complicated hemorrhagic fever were randomly divided into two groups. The experimental group (25 cases) were treated with ulinastatin and the control group (25 cases) with 5% sugar solution as blank control. In addition, the patients in the experimental group were divided into two groups according to the time of fever. Group A (n = 9) had fever for 1 d and group B (n = 16) for 5 d. All patients were measured and compared with urinary microprotein, serum creatinine and plasma albumin 7 days after treatment. Results: compared with the control group, the urinary trace protein decreased significantly in the experimental group, the recovery rate of serum creatinine was faster, the plasma albumin increased significantly, the time of occurrence of urinary oligocytoma was significantly decreased, the time of complications was also decreased. The difference was statistically significant (P 0.05). Compared with the control group B, the urinary microalbuminuria of the experimental group A decreased significantly; the recovery rate of serum creatinine was faster; the plasma albumin increased significantly; the time of complications also decreased significantly; the difference was statistically significant (P 0.05). Conclusion: ulinastatin is effective in the treatment of capillary leakage syndrome, and is the best in the early stage of fever.
【作者单位】： 广州市第八人民医院急诊科;
【基金】：广州市科技计划项目(编号:201607010302)
【分类号】：R512.8
【参考文献】
相关期刊论文 前8条
1 吴莉春;林联韵;江峰;;尿微量蛋白及尿酶联合检测在糖尿病早期肾损伤诊断中的临床意义[J];医学理论与实践;2016年15期
2 吴琼;金作林;李欣;王丽颖;刘佳;;复合干细胞膜片移植修复后的牙周组织与正常牙周组织对正畸力反应的差异性研究[J];口腔疾病防治;2016年07期
3 彭娜;耿焱;张爽;唐柚青;文强;刘云松;苏磊;;乌司他丁对中暑大鼠肾损伤及氧化应激的影响[J];解放军医学杂志;2015年05期
4 王小玲;;肾综合征出血热肾损害的超声表现[J];中国医药指南;2014年29期
5 杜虹;李t，
本文编号：2157289
本文链接：https://www.wllwen.com/yixuelunwen/chuanranbingxuelunwen/2157289.html
最近更新
教材专著
