基于医院信息系统的手足口病合并症及用药研究

发布时间：2018-08-07 21:14

【摘要】：目的探讨我国手足口病(HFMD)患者的合并症情况及用药规律。方法在中国中医科学院中医临床基础研究所建立的数据仓库中,选取2006年11月—2011年6月9家三级甲等综合医院医院信息系统(HIS)记录的941例第一诊断为HFMD患者的住院信息。对患者的一般信息、合并症情况进行描述性统计分析,采用频数分析法、关联分析探讨患者的用药情况。结果共625例患者记录了年龄,其中1~6岁601例(96.2%)。941例患者均记录了合并症,发生率排在前3位的合并症分别为肺炎(3.9%,37/941)、发热(1.4%,13/941)、贫血(1.3%,12/941)。720例患者记录了用药情况,使用率排在前3位的西药分别为维生素(82.8%,596/720)、氯化钾(33.2%,239/720)、地塞米松(25.6%,184/720),使用率排在前3位的中药分别为板蓝根(14.4%,104/720)、抗病毒感冒颗粒(10.1%,73/720)、咳喘宁(2.5%,18/720)。关联分析结果显示,在1类中药+1/2/3类西药的组合方式中,联合使用率排在首位的分别为板蓝根+重组人干扰素、板蓝根+匹多莫德+重组人干扰素、板蓝根+对乙酰氨基酚+匹多莫德+重组人干扰素。在常用中、西药物中,抗病毒感冒颗粒与维生素经常联合使用,板蓝根与维生素联合使用次之。结论真实世界中应将1~6岁儿童作为HFMD的重点预防人群,合并症多由感染引起,以临床常用中、西药联合使用的治疗模式最为常见,同时应注意营养支持和预防感染,清热解毒类中药与抗生素联合最为常用。
[Abstract]:Objective to investigate the complications of hand, foot and mouth disease (HFMD) in China. Methods from November 2006 to June 2011, 941 patients with HFMD were selected from the data warehouse established by the Institute of Clinical Research of Chinese Academy of traditional Chinese Medicine (CAS). The data were collected from 9 Grade 3A General Hospitals Information system (HIS) from November 2006 to June 2011. The general information and complications of patients were analyzed by descriptive statistics, frequency analysis and association analysis were used to discuss the drug use. Results Age was recorded in 625 patients, including 601 cases (96.2%) of 1 or 6 years of age and 941 cases of complications. The incidence of complications in the top 3 cases were pneumonia (3.937 / 941), fever (1.4% 13 / 941), anemia (1.312 / 941) .720 cases (n = 720). The top three Western medicines were vitamins (82.8n 596 / 720), potassium chloride (33.2 / 239 / 720), dexamethasone (25.6T / 720). The top three Chinese medicines were Radix Isatidis (14.4 / 104 / 720), Anti-virus and Cold granules (10.1 / 73 / 720) and Kechuanning (2.5n 18-720). The results of association analysis showed that in the combination of western medicine of class 1 in 1-2-3, the combined utilization rate was ranked first in the combination of recombinant human interferon in Isatis root, recombinant human interferon in pinidomod of Isatis langenensis, and in the combination mode of combination of western medicine of Chinese medicine in 1-2-3. Isatis root paracetamol acetaminophen pidomod recombinant human interferon. In common use, western medicine, antiviral colds granules and vitamins are often used in combination, Isatis root and vitamin combination next. Conclusion in the real world, children aged 1 to 6 should be regarded as the most important prevention population of HFMD, and the complications are mostly caused by infection. The treatment mode of combined use of western medicine is the most common in clinical use, and attention should be paid to nutrition support and prevention of infection. The combination of antipyretic and antitoxic Chinese medicine and antibiotics is the most commonly used.
【作者单位】： 中国中医科学院针灸研究所;中国中医科学院中医临床基础医学研究所;
【基金】：中央级公益性科研院所基本科研业务费专项资金(PY1303、Z00406)
【分类号】：R512.5
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本文编号：2171362