2011年广西部分地区HIV耐药株发生情况分析

发布时间：2018-08-11 08:46

【摘要】：目的了解广西部分地区已接受高效抗反转录病毒治疗(HAART)的病人中,艾滋病病毒(HIV)耐药株的发生情况。方法对南宁市和崇左市2011年已接受HAART6个月的病人,进行横断面调查并采集血液样本检测HIV-1病毒载量,对病毒载量1000拷贝/mL的样本进行耐药基因型分析。结果两市共调查并成功采集了1472例病人的血液样本,病毒未抑制率为4.6%(68/1472),最终获得64份序列用于耐药分析。发现对非核苷类反转录酶抑制剂(NNRTIs)和核苷类反转录酶抑制剂(NRTIs)最主要耐药突变位点分别为G190A和M184V,未发现蛋白酶类抑制剂(PIs)有耐药突变,3类药物的耐药率分别为1.9%(28/1468)、1.6%(24/1468)和0.0%(0/1468),总耐药率为3.5%(52/1468)。52例病人出现了耐药,其中43.8%(28/64)病毒抑制失败病人对NNRTIs耐药,37.5%(24/64)对NRTIs耐药,29.7%(19/64)对NNRTIs和NRTIs双重耐药,81.3%(52/64)至少对某类药物有耐药。结论两个地区2011年已接受HAART人群中,HIV耐药株发生率较低,但出现了对NNRTIs和NRTIs双重耐药,值得关注。
[Abstract]:Objective to investigate the incidence of HIV (HIV) resistant strains in patients with (HAART) who have been treated with highly effective antiretroviral therapy in some areas of Guangxi. Methods the patients in Nanning and Chongzuo who had received HAART6 for several months in 2011 were investigated cross-sectional and blood samples were collected to detect the load of HIV-1 virus. The drug resistant genotypes of 1000 copies / mL samples were analyzed. Results A total of 1472 blood samples were collected from the two cities. The uninhibited rate of the virus was 4.6% (68 / 1472). Finally, 64 sequences were obtained for drug resistance analysis. G190A and M188V were found to be the most important mutation sites for (NNRTIs) and (NRTIs), respectively. The resistant rates of (PIs) were 1.9% (28 / 1468) and 1.6% (24 / 1468), respectively. And 0% (0 / 1468), the total drug resistance rate was 3.5% (52 / 1468). Of these, 43.8% (28 / 64) failed to inhibit NNRTIs resistance (37.5% (24 / 64) to NRTIs, 29.7% (19 / 64) to NNRTIs and NRTIs, 81.3% (52 / 64) to at least one drug class. Conclusion the incidence of HAART resistant strains in the two regions was low in 2011, but dual drug resistance to NNRTIs and NRTIs was found, which is worthy of attention.
【作者单位】：广西壮族自治区疾病预防控制中心;
【基金】：广西壮族自治区卫生厅自筹经费科研课题(Z2010033)~~
【分类号】：R512.91

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