血常规、Child-Pugh分级、肝功能、HBV-DNA在HBeAg阴性及阳性乙肝肝硬化患者中的对比分析

发布时间：2018-08-21 20:35

【摘要】：目的探讨血常规、Child-Pugh分级、肝功能及HBV-DNA在HBe Ag阴性及阳性乙肝肝硬化患者中的区别,分析HBe Ag阴性及阳性与乙肝肝硬化患者疾病进展间的关系。方法选取2013年2月至2015年2月间收治的乙肝肝硬化患者215例,根据HBe Ag检测结果分成HBe Ag阴性组(137例)与HBe Ag阳性组(78例)。分别检测两组患者的血常规指标白细胞计数(WBC)、血小板计数(PLT)、血红蛋白(HB),肝功能指标丙氨酸氨基转移酶(ALT)、血清总胆红素(TBIL)、白蛋白(ALB)、前白蛋白(PA)、凝血酶原活动度(PTA)及HBV-DNA荧光定量PCR检测;并分别记录两组患者的性别构成比、年龄、病程及Child-Pugh分级。结果两组患者性别构成及病程方面比较差异无统计学意义(P0.05);HBe Ag阴性组年龄显著大于阳性组,差异有统计学意义(P0.05)。HBe Ag阴性组血常规指标WBC及PLT均显著低于阳性组,差异有统计学意义(P0.05);HBe Ag阴性组肝功能指标ALT显著低于阳性组,差异有统计学意义(P0.05);在Child-Pugh分级方面,HBe Ag阴性组B级患者比例显著低于阳性组,而C级患者比例显著高于阳性组,差异均有统计学意义(P0.05);HBe Ag阴性组HBV-DNA荧光定量检测的阳性率显著低于阳性组,差异均有统计学意义(P0.05)。结论与HBe Ag阳性肝硬化患者相比,HBe Ag阴性患者的肝硬化程度及炎症反应较为严重,且肝脏储备功能较差;但HBe Ag阳性患者应该更加积极地配合治疗,以防止HBV突变株的产生、肝硬化的加重及进展成为肝癌。
[Abstract]:Objective to investigate the difference of Child-Pugh grade, liver function and HBV-DNA in patients with HBe Ag negative and positive hepatitis B cirrhosis, and to analyze the relationship between HBe Ag negative and positive HBe Ag and the progression of hepatitis B cirrhosis. Methods 215 patients with hepatitis B cirrhosis admitted from February 2013 to February 2015 were divided into HBe Ag negative group (137 cases) and HBe Ag positive group (78 cases) according to the results of HBe Ag test. WBC count (WBC), platelet count (PLT), hemoglobin (HB), liver function index alanine aminotransferase (ALT), serum total bilirubin (TBIL), albumin (ALB), prealbumin (PA), prothrombin activity (PTA) and HBV-DNA fluorescence quantitative PCR detection; The sex composition ratio, age, course of disease and Child-Pugh grade of the two groups were recorded. Results there was no significant difference in sex composition and course of disease between the two groups (P0.05). The age of HBe Ag negative group was significantly larger than that of positive group, and the difference was statistically significant (P0.05). The blood routine indexes WBC and PLT in HBe Ag negative group were significantly lower than those in positive group. The difference was statistically significant (P0.05) in HBe Ag negative group compared with the positive group (P0.05), the proportion of HBe Ag negative group B group was significantly lower than that of the positive group, and the proportion of C grade group was significantly higher than that of the positive group (P0.05). The positive rate of HBV-DNA fluorescence quantitative detection in HBe Ag negative group was significantly lower than that in positive group (P0.05). Conclusion compared with the patients with HBe Ag positive cirrhosis, the degree of cirrhosis and inflammatory reaction in patients with HBe Ag negative is more serious, and the liver reserve function is poor, but the patients with positive HBe Ag should cooperate more actively with the treatment to prevent the production of HBV mutants. The exacerbation and progression of cirrhosis become liver cancer.
【作者单位】：深圳市第三人民医院检验科;深圳市第三人民医院肝病科;
【分类号】：R512.62

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