2012-2013年福州市手足口病原学调查研究

发布时间：2018-08-25 18:26

【摘要】：目的对2012-2013年福州市手足口病进行病原学调查研究并对其流行病学特征进行分析,旨在全面了解福州地区手足口病的肠道病毒。方法收集2012-2013年福州市区临床表现为手足口病的样本1 031份,通过荧光定量RT-PCR、巢式RT-PCR以及NCBI提供的BLAST序列比对确定肠道病毒型别。利用CVA6特异性引物鉴定2012-2013年福州市其他肠道病毒。对2012年CVA6手足口病例进行流行病学特征分析。结果 1 031份标本中878份显示EV阳性,检出率为85.16%(878/1 031),其中EV71 426例,阳性率为45.52%(426/878);CVA16 93例,阳性率为10.60%(93/878);其他肠道病毒359例,阳性率为40.88%(359/878),其中CVA6为218例,阳性率为24.83%(218/878)。另还发现CVA10和Echo3肠道病毒。流行病学特征分析发现0~5岁年龄组儿童为CVA6主要发病人群(构成比为94.04%),男女性别比为1.66∶1;CVA6构成比情况在各月有较大差异,总体起伏明显,9月的CVA6病例构成比占62.50%,达到2012年最高峰。结论 EV71、CVA16和CVA6是福州市手足口的主要肠道病原体,CVA6病毒已经超过CVA16成为第二大病原体,2012年CVA6主要发病人群为0~5岁儿童,9月份为发病高峰期。
[Abstract]:Objective to investigate the etiology and epidemiological characteristics of hand, foot and mouth disease (HFMD) in Fuzhou from 2012 to 2013 in order to understand the enterovirus of HFMD in Fuzhou. Methods 1,031 samples of hand-foot-mouth disease (HFMD) were collected in Fuzhou from 2012 to 2013. The enterovirus types were determined by fluorescence quantitative RT-PCR, nested RT-PCR and BLAST sequence alignment provided by NCBI. CVA6 specific primers were used to identify other enterovirus in Fuzhou from 2012-2013. The epidemiological characteristics of hand, foot and mouth disease (HFMD) of CVA6 in 2012 were analyzed. Results the positive rate of EV was 85.16% (878 / 1031) in 1 031 specimens, 45.52% (45.52%) of 45.52% (45.52%), the positive rate was 10.60% (93 / 878), and the positive rate of other enterovirus was 40.88% (359878). The positive rate of CVA6 was 24.83% (218878). CVA10 and Echo3 enterovirus were also found. Epidemiological analysis showed that children aged 0 to 5 years old were the main incidence of CVA6 (compositional ratio was 94.04%), and the sex ratio of male and female was 1.66: 1 and CVA6 was different from month to month. The overall fluctuation was obvious, the proportion of CVA6 cases in September accounted for 62.50%, reaching the highest peak in 2012. Conclusion EV71,CVA16 and CVA6 are the main enteric pathogens in Fuzhou City. CVA6 virus has surpassed CVA16 to become the second major pathogen. The peak of CVA6 infection in 2012 is 0 ~ 5 years old children in September.
【作者单位】：福州市疾病预防控制中心;福建医科大学;
【分类号】：R512.5

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