细胞凋亡蛋白抑制因子2在乙型肝炎相关性肝癌患者中的表达意义

发布时间：2018-08-31 14:46

【摘要】：目的研究细胞凋亡蛋白抑制因子2(cIAP2)在乙型肝炎(简称乙肝)和非乙肝相关性肝癌患者中表达的意义。方法收集该院肝癌切除术患者的病例资料和组织标本,分别利用免疫组织化学和Western blot方法检测患者肝癌癌灶、癌旁和远癌旁肝组织的cIAP2蛋白表达情况。结果在两组患者中肝癌癌灶、癌旁和远癌旁肝组织中,cIAP2的表达量依次下降。但是,在非乙肝相关性肝癌组中,远癌旁肝组织的cIAP2表达显著低于肝癌癌灶和癌旁,而在乙肝相关性肝癌组中,远癌旁肝组织的cIAP2表达量与癌旁的cIAP2表达量无明显差异,却低于癌灶的cIAP2表达量。结论 cIAP2是引起乙肝相关性肝癌发生的重要机制之一,可作为乙肝相关性肝癌患者抑制肝癌发展和清除乙肝病毒潜在的治疗靶点。
[Abstract]:Objective to study the expression of apoptosis protein inhibitor 2 (cIAP2) in patients with hepatitis B (HBV) and non-hepatitis B associated hepatocellular carcinoma (HCC). Methods the data and tissue samples of patients undergoing hepatectomy were collected, and the expression of cIAP2 protein was detected by immunohistochemical and Western blot methods in the liver tissues of the patients with hepatocellular carcinoma (HCC), paracancerous and paracancerous tissues. Results in both groups, the expression of cIAP2 in HCC, paracancerous and paracancerous liver tissues decreased in turn. However, in the non-HBV-associated liver cancer group, the expression of cIAP2 in the distal adjacent liver tissue was significantly lower than that in the cancer focus and adjacent liver cancer group, but there was no significant difference between the expression of cIAP2 and the cIAP2 expression in the adjacent liver tissue in the HBV-associated liver cancer group. However, the expression of cIAP2 was lower than that of cancer focus. Conclusion cIAP2 is one of the important mechanisms of Hepatitis B associated liver cancer, and it can be used as a potential therapeutic target for inhibiting the development of liver cancer and eliminating hepatitis B virus in patients with hepatitis B associated liver cancer.
【作者单位】：遂宁市中心医院病理科;
【分类号】：R735.7;R512.62

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