丙肝病毒性肝硬化及非酒精性脂肪肝患者血清脑钠肽水平与肝脏疾病严重程度及心脏功能的相关性研究

发布时间：2018-09-07 11:34

【摘要】：目的:探讨丙肝病毒性肝硬化及非酒精性脂肪肝患者血清脑钠肽(BNP)水平与肝脏疾病严重程度及心脏功能的相关性。方法:选取丙肝病毒性肝硬化患者55例为肝硬化组,非酒精性脂肪肝患者55例为脂肪肝组,健康志愿者25例为对照组。对3组研究对象进行完整的体格检查,测定血红蛋白水平、肝肾功能生化指标、BNP,通过心电图、超声心动图检查心脏功能指标。结果:肝硬化组患者血清BNP水平显著高于其余两组(P0.05),并与肝脏疾病严重程度相关(P0.05);代谢失代偿的肝硬化患者BNP水平显著高于无失代偿的患者;脂肪肝组患者血清BNP水平较对照组差异无统计学意义,且与脂肪肝严重程度无相关性。二维心脏彩超检查显示室间隔厚度(IVST)11 mm、舒张期后壁厚度(PWT)11 mm、左心房内径(LA)40 mm、左心室射血分数(EF)54%以及左室早期舒张充盈峰值速度与心房收缩晚期充盈波峰值速率的比值(E/A值)1的肝硬化和脂肪肝患者血清BNP水平显著高于未出现上述情况的患者(P0.05)。结论:血清BNP水平与肝硬化严重程度及心脏功能变化存在相关性,其对肝病严重程度及心脏功能的监测具有重要意义。
[Abstract]:Objective: to investigate the relationship between the level of serum brain natriuretic peptide (BNP) (BNP) and the severity of liver disease and heart function in patients with hepatitis C cirrhosis and non alcoholic fatty liver. Methods: 55 patients with hepatitis C cirrhosis, 55 patients with non-alcoholic fatty liver and 25 healthy volunteers were selected as control group. The complete physical examination, hemoglobin level, liver and kidney function biochemical index (BNPs), cardiac function index were examined by electrocardiogram and echocardiography. Results: the serum BNP level in patients with liver cirrhosis was significantly higher than that in the other two groups (P0.05), and was correlated with the severity of liver disease (P0.05), and the level of BNP in patients with metabolic decompensation was significantly higher than that in patients without decompensation. There was no significant difference in serum BNP level between the fatty liver group and the control group, and there was no correlation between the level of serum BNP and the severity of fatty liver. Two-dimensional echocardiography showed that ventricular septal thickness, (IVST) 11 mm, posterior diastolic wall thickness, (PWT) 11 mm, left atrial diameter, (LA) 40 mm, left ventricular ejection fraction (EF) 54%, left ventricular early diastolic filling peak velocity and peak rate of late atrial systolic filling wave were detected by echocardiography. The serum BNP levels in cirrhosis and fatty liver patients with ratio 1 (E / A) were significantly higher than those without (P0.05). Conclusion: the level of serum BNP is correlated with the severity of liver cirrhosis and the changes of cardiac function, which is of great significance in monitoring the severity of liver disease and cardiac function.
【作者单位】：咸阳市中心医院肝胆外科;洛川县医院神经内科;
【分类号】：R575;R512.63

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