HBeAg阴性慢性乙肝合并肝硬化患者血清HBV-DNA水平与肝功能的关系

发布时间：2018-09-10 17:22

【摘要】：目的探讨HBeAg阴性慢性乙肝合并肝硬化患者血清HBV-DNA水平与肝功能的相关性,以便为慢性乙肝合并肝硬化患者的诊疗提供参考。方法选择HBeAg阴性慢性乙肝合并肝硬化患者61例(观察组)和HBeAg阴性慢性乙肝无肝硬化患者70例(对照组);采用全自动生化仪测定两组血清谷草转氨酶(AST)、谷丙转氨酶(ALT)、白蛋白(A)及球蛋白(G)等肝功能指标;采用免疫比浊法、速率法分别测定血清透明质酸(HA)、单胺氧化酶(MAO)等肝纤维化指标。采用Pearson相关分析患者血清HBV-DNA水平与肝功能及纤维化指标的关系。结果观察组血清HBV-DNA、AST/ALT、HA及MAO高于对照组,ALT、A、A/G低于对照组,差异具有统计学意义(P均0.05)。血清HBV-DNA水平与AST/ALT、HA及MAO指标呈正相关(r分别为0.396、0.438、0.514,P均0.05),与A/G呈负相关(r=-0.362,P0.05)。结论 HBeAg阴性慢性乙肝合并肝硬化患者病毒载量的升高可导致肝实质损伤、肝脏储备功能下降及肝组织发生纤维化,HBV-DNA定量分析可指导乙肝合并肿硬化患者的临床诊治。
[Abstract]:Objective to investigate the correlation between serum HBV-DNA level and liver function in patients with chronic hepatitis B (HBeAg) negative liver cirrhosis and to provide reference for diagnosis and treatment of chronic hepatitis B patients with cirrhosis. Methods 61 HBeAg negative chronic hepatitis B patients with liver cirrhosis and 70 HBeAg negative chronic hepatitis B patients without cirrhosis (control group) were selected and the serum glutamic oxaloacetic transaminase (AST),) transaminase was measured by automatic biochemical instrument in both groups. Liver function indexes such as enzyme (ALT), albumin (A) and globulin (G); Serum hyaluronic acid (HA),) monoamine oxidase (MAO) and serum hyaluronic acid (HA),) monoamine oxidase (MAO) were determined by immunoturbidimetry and rate method respectively. The relationship between serum HBV-DNA level and liver function and fibrosis index was analyzed by Pearson correlation. Results the levels of serum HBV-DNA,AST/ALT,HA and MAO in the observation group were significantly higher than those in the control group (P < 0. 05). The level of serum HBV-DNA was positively correlated with AST/ALT,HA and MAO (r = 0.396P = 0.4380.5314, respectively), and negatively correlated with A / G (r = 0.362P 0.05). Conclusion the increase of viral load in HBeAg negative chronic hepatitis B patients with cirrhosis can lead to liver parenchymal injury. The decrease of liver reserve function and the quantitative analysis of HBV-DNA in liver tissue fibrosis can guide the clinical diagnosis and treatment of patients with hepatitis B complicated with tumor sclerosis.
【作者单位】：成都医学院第一附属医院;
【分类号】：R512.62;R575.2

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