抗病毒治疗1年后的疗效评价及病毒抑制失败影响因素分析
发布时间:2018-10-09 13:37
【摘要】:目的了解抗艾滋病病毒(HIV)治疗情况并进行疗效评价,探索抗病毒治疗(ART)病毒抑制失败的影响因素,提出改进ART效果的措施。方法收集成都市疾病预防控制中心性病艾滋病防治科所提供的成都市HIV感染者/艾滋病(AIDS)病人(简称HIV/AIDS病人)抗病毒治疗的随访资料,对资料进行清理分析。结果共收集1682例HIV/AIDS病人,经标准方案治疗1年后CD_4~+T淋巴细胞计数从(184.49±103.82)个/μL上升到(313.11±157.41)个/μL,ART前后差异有统计学意义(t=-40.778,P0.001)。病毒抑制失败86例,失败率为5.1%。拟合多因素Logistic回归分析发现,年龄[比值比(OR)=2.073,95%可信区间(CI)=1.012~4.248,P=0.046]、漏服(OR=5.994,95%CI=2.314~15.528,P0.001)及治疗方案(OR=2.059,95%CI=1.223~3.467,P=0.007)与病毒抑制失败的关系具有统计学意义。结论漏服是影响病毒抑制失败的主要因素,应关注老年患者的病毒抑制情况,通过提高患者依从性和尽量使用最优治疗方案来降低病毒抑制失败率。
[Abstract]:Objective to investigate the effect of anti-HIV (HIV) treatment and evaluate its efficacy, to explore the factors influencing the failure of anti-HIV treatment of (ART) virus, and to put forward the measures to improve the effect of ART. Methods the follow-up data of HIV / (AIDS) patients (HIV/AIDS patients) provided by STD / AIDS Department of Chengdu Center for Disease Control and Prevention were collected and analyzed. Results A total of 1682 patients with HIV/AIDS were collected. The number of CD_4~ T lymphocytes increased from (184.49 卤103.82) / 渭 L to (313.11 卤157.41) / 渭 L after 1 year's treatment with standard regimen. 86 cases of virus inhibition failed, the failure rate was 5.1%. Multivariate Logistic regression analysis showed that age [ratio than (OR) 2.073% confidence interval (CI) 1.0124.248P0. 046], OR=5.994,95%CI=2.314~15.528,P0.001 and treatment regimen (OR=2.059,95%CI=1.223~3.467,P=0.007) were significantly correlated with the failure of virus suppression. Conclusion the failure rate of virus suppression should be reduced by increasing compliance of patients and using optimal treatment regimen.
【作者单位】: 四川大学华西公共卫生学院流行病与卫生统计学系;成都市疾病预防控制中心;
【分类号】:R512.91
本文编号:2259532
[Abstract]:Objective to investigate the effect of anti-HIV (HIV) treatment and evaluate its efficacy, to explore the factors influencing the failure of anti-HIV treatment of (ART) virus, and to put forward the measures to improve the effect of ART. Methods the follow-up data of HIV / (AIDS) patients (HIV/AIDS patients) provided by STD / AIDS Department of Chengdu Center for Disease Control and Prevention were collected and analyzed. Results A total of 1682 patients with HIV/AIDS were collected. The number of CD_4~ T lymphocytes increased from (184.49 卤103.82) / 渭 L to (313.11 卤157.41) / 渭 L after 1 year's treatment with standard regimen. 86 cases of virus inhibition failed, the failure rate was 5.1%. Multivariate Logistic regression analysis showed that age [ratio than (OR) 2.073% confidence interval (CI) 1.0124.248P0. 046], OR=5.994,95%CI=2.314~15.528,P0.001 and treatment regimen (OR=2.059,95%CI=1.223~3.467,P=0.007) were significantly correlated with the failure of virus suppression. Conclusion the failure rate of virus suppression should be reduced by increasing compliance of patients and using optimal treatment regimen.
【作者单位】: 四川大学华西公共卫生学院流行病与卫生统计学系;成都市疾病预防控制中心;
【分类号】:R512.91
【参考文献】
相关期刊论文 前1条
1 ;2015年5月全国艾滋病性病疫情及主要防治工作进展[J];中国艾滋病性病;2015年07期
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