社区乙型肝炎表面抗原阳性人群血清流行病学特征分析
发布时间：2018-10-26 13:36
【摘要】：目的了解社区乙型肝炎表面抗原(HBs Ag)阳性人群血清流行病学特征,为乙型肝炎防治示范区现场研究提供基础数据。方法选取武威市2010—2014年乙型肝炎防治示范区经社区健康体检筛选及各社区卫生服务中心报告的HBs Ag阳性者为研究对象。采用自制的调查问卷收集研究对象人口学特征以及治疗情况。采集研究对象静脉血,检测HBs Ag、乙型肝炎表面抗体(HBs Ab)、乙型肝炎e抗原(HBe Ag)、乙型肝炎e抗体(HBe Ab)、乙型肝炎核心抗体(HBc Ab)等血清学指标,以及丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、总胆红素(TBIL)、直接胆红素(DBIL)、谷氨酸转肽酶(GGT)、清蛋白(ALB)及甲胎蛋白(AFP)水平等生化指标。结果本研究获得由社区健康体检筛选或社区卫生服务中心报告的HBs Ag阳性者3 678例。HBs Ag阳性者血清学共有14种组合模式,HBs Ag、HBe Ab、HBc Ab阳性模式(模式1)占69.06%(2 540/3 678),HBs Ag、HBc Ab阳性模式(模式2)占13.30%(489/3 678),HBs Ag、HBe Ag、HBc Ab阳性模式(模式3)占11.56%(425/3 678)。不同主要血清学模式的HBs Ag阳性者性别、年龄、婚姻状况、文化程度、职业、体质指数及乙型肝炎家族史比较,差异均有统计学意义(P0.05)。HBe Ag阳性者ALT、AST水平高于HBe Ag阴性者,GGT、ALB水平低于HBe Ag阴性者(P0.05)。ALT水平≤2或2倍参考范围上限者中,HBe Ag阳性与阴性者定期复查、药物治疗及因乙型肝炎住院治疗比例比较,差异均无统计学意义(P0.05)。结论武威市社区HBs Ag阳性人群血清学以HBs Ag、HBe Ab、HBc Ab阳性模式为主,HBe Ag阳性与阴性者抗病毒药物治疗率均较低。
[Abstract]:Objective to investigate the seroepidemiological characteristics of hepatitis B surface antigen (HBs Ag) positive population in community, and to provide basic data for the field study of hepatitis B prevention and control demonstration area. Methods the patients with HBs Ag positive from 2010 to 2014 were selected from the community health checkup screening and the community health service centers in the prevention and treatment demonstration area of hepatitis B in Wuwei city from 2010 to 2014. A self-made questionnaire was used to collect the demographic characteristics and treatment of the subjects. HBs Ag, hepatitis B surface antibody (HBs Ab), hepatitis B e antigen (HBe Ag), hepatitis B e antibody (HBe Ab), hepatitis B core antibody (HBc Ab) and other serological indexes were detected. And the biochemical indexes of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), direct bilirubin (DBIL), glutamate transpeptidase (GGT), albumin (ALB) and alpha-fetoprotein (AFP). Results in this study, 3 678 HBs Ag positive individuals who were screened by community health checkup or reported by community health service center had 14 combinations of. HBs Ag positive serological models, HBs Ag,HBe Ab,. HBc Ab positive pattern (mode 1) accounted for 69.06% (2540 / 3 678), HBs Ag,HBc Ab) positive pattern (mode 2) accounted for 13.30% (489 / 3 678), HBs Ag,HBe Ag,) HBc Ab positive pattern (mode 3) accounted for 11.56% (425 / 3678). Gender, age, marital status, education, occupation, body mass index and family history of hepatitis B were significantly different among HBs Ag positive patients with different serological patterns (P0.05). The level of AST was higher than that of HBe Ag negative, and the GGT,ALB level was lower than that of HBe Ag negative (P0.05). ALT level 鈮，
本文编号：2295885
[Abstract]:Objective to investigate the seroepidemiological characteristics of hepatitis B surface antigen (HBs Ag) positive population in community, and to provide basic data for the field study of hepatitis B prevention and control demonstration area. Methods the patients with HBs Ag positive from 2010 to 2014 were selected from the community health checkup screening and the community health service centers in the prevention and treatment demonstration area of hepatitis B in Wuwei city from 2010 to 2014. A self-made questionnaire was used to collect the demographic characteristics and treatment of the subjects. HBs Ag, hepatitis B surface antibody (HBs Ab), hepatitis B e antigen (HBe Ag), hepatitis B e antibody (HBe Ab), hepatitis B core antibody (HBc Ab) and other serological indexes were detected. And the biochemical indexes of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), direct bilirubin (DBIL), glutamate transpeptidase (GGT), albumin (ALB) and alpha-fetoprotein (AFP). Results in this study, 3 678 HBs Ag positive individuals who were screened by community health checkup or reported by community health service center had 14 combinations of. HBs Ag positive serological models, HBs Ag,HBe Ab,. HBc Ab positive pattern (mode 1) accounted for 69.06% (2540 / 3 678), HBs Ag,HBc Ab) positive pattern (mode 2) accounted for 13.30% (489 / 3 678), HBs Ag,HBe Ag,) HBc Ab positive pattern (mode 3) accounted for 11.56% (425 / 3678). Gender, age, marital status, education, occupation, body mass index and family history of hepatitis B were significantly different among HBs Ag positive patients with different serological patterns (P0.05). The level of AST was higher than that of HBe Ag negative, and the GGT,ALB level was lower than that of HBe Ag negative (P0.05). ALT level 鈮，
本文编号：2295885
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