艾滋病患者骨髓细胞学特征分析

发布时间：2018-11-17 19:55

【摘要】：目的探讨获得性免疫缺陷综合征(AIDS)患者骨髓细胞学特征,对艾滋病的快速诊断提供依据。方法采用回顾性研究的方法,对医院2011年1月-2012年5月278例AIDS患者骨髓细胞学检查结果进行统计分析。结果取材满意189份,占68.0%,其中95.8%以上有核细胞增生活跃;常见细胞学异常表现型及分布率依次是淋巴细胞减少84.7%、红细胞核形态异常71.4%、红细胞缗钱状排列59.8%、血小板减少55.0%、中性粒细胞核发育异常54.5%、粒红比值升高45.5%、巨核细胞成熟障碍32.3%、组织细胞活化24.9%,其中淋巴细胞减少、中性粒细胞核发育异常、红细胞核形态异常、红细胞缗钱状排列和血小板分布减少的比率与其他表现型比较差异有统计学意义(P0.05);在取材满意病例中,镜检检出马尔尼菲青霉菌(penicillium marneffei,PM)阳性36例、淋巴瘤细胞2例。结论 AIDS患者的骨髓细胞学特点主要表现为粒细胞、红细胞、巨核细胞系统一系或多系病态造血,淋巴细胞比率减低,常伴组织细胞反应性增殖或活化,南方地区患者于涂片中较易见PM。
[Abstract]:Objective to investigate the characteristics of bone marrow cytology in patients with acquired immunodeficiency syndrome (AIDS) and to provide evidence for rapid diagnosis of AIDS. Methods the results of bone marrow cytology in 278 patients with AIDS from January 2011 to May 2012 were analyzed retrospectively. Results 189 samples were obtained, accounting for 68.0%, of which more than 95.8% had active proliferation of nucleated cells. The common cytological abnormal phenotypes and distribution rates were lymphocytopenia 84.7, red cell nucleus 71.4, erythrocyte roulein 59.8, thrombocytopenia 55.0, erythrocyte roulein 59.8, thrombocytopenia 55.0. The ratio of neutrophil nucleus to neutrophils was 54.5%, the ratio of granulocyte to red was increased 45.5%, the megakaryocyte maturation disorder was 32.3%, the activation of histocyte was 24.9%, in which lymphocytes were decreased, and the nucleus of neutrophil was abnormal. The ratio of erythrocyte karyotype abnormality, erythrocyte roulein arrangement and thrombocytopenia were significantly different from those of other phenotypes (P0.05). Among the satisfactory cases, 36 cases were positive for Penicillium marneffei (penicillium marneffei,PM) and 2 cases were lymphoma cells. Conclusion the main features of bone marrow cytology in AIDS patients are granulocyte, erythrocyte, megakaryocyte system with one or more lineage of morbid hematopoiesis, and the ratio of lymphocytes is decreased, which is often accompanied by reactive proliferation or activation of histocyte. PM. is more easily seen in smears of patients in southern China
【作者单位】：南宁市第四人民医院广西艾滋病临床治疗中心(南宁);
【基金】：广西壮族自治区卫生厅科研基金资助项目(Z20120631)
【分类号】：R512.91

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