干扰素对慢性丙肝患者T淋巴细胞亚群及甲状腺功能的影响

发布时间：2018-11-20 12:55

【摘要】：目的分析干扰素对慢性丙肝患者CD_4~+CD_(25)~+Treg细胞及甲状腺功能的影响,为临床治疗提供参考依据。方法选取医院2012年5月-2015年5月收治的80例慢性丙型病毒性肝炎患者,依据随机数表法分成观察组与对照组,各40例;对照组予以常规药物治疗,观察组予以干扰素治疗,观察两组患者治疗后各项指标水平变化及不良反应率。结果治疗后,观察组CD_4~+CD_(25)~+Treg细胞为(7.52±1.10)%、对照组为(8.21±1.13)%,两组比较差异有统计学意义(P0.05);观察组谷草转氨酶(AST)、谷丙转氨酶(ALT)、总胆红素(TbiL)、直接胆红素(DbiL)低于对照组(P0.05);两组不良反应率比较差异无统计学意义。结论干扰素对慢性丙型肝炎患者的治疗效果比较确切,对甲状腺的功能影响较小,能够明显地改善患者的肝功能,降低CD_4~+CD_(25)~+Treg细胞水平,调节机体免疫应答反应,促进患者康复。
[Abstract]:Objective to analyze the effects of interferon on CD_4~ CD_ (25) ~ Treg cells and thyroid function in patients with chronic hepatitis C. Methods from May 2012 to May 2015, 80 patients with chronic hepatitis C were selected and divided into two groups: observation group (n = 40) and control group (n = 40). The patients in the control group were treated with routine drugs, and the patients in the observation group were treated with interferon. Results after treatment, the CD_4~ CD_ (25) ~ Treg cells were (7.52 卤1.10)% in the observation group and (8.21 卤1.13)% in the control group. The difference between the two groups was statistically significant (P0.05). The total bilirubin (DbiL) of total bilirubin (TbiL), (TbiL), in the observation group was lower than that in the control group (P0.05); there was no significant difference in the adverse reaction rate between the two groups. Conclusion Interferon is effective in the treatment of chronic hepatitis C and has little effect on thyroid function. It can obviously improve the liver function of patients and decrease the level of CD_4~ CD_ (25) ~ Treg cells. Regulate the immune response of the body and promote the recovery of patients.
【作者单位】：河南科技大学附属三门峡市中心医院感染性疾病科;
【分类号】：R512.63

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