广州地区腹泻患者轮状病毒感染的流行病学研究

发布时间：2018-11-20 15:58

【摘要】：目的了解广州地区患者腹泻中轮状病毒(RV)感染与性别、年龄、季节的关系以及RV感染率现状,为临床诊断、治疗和预防提供可靠实验数据。方法收集医院2010年1月-2012年12月住院和门诊的腹泻患者粪便标本2 164份,采用免疫层析双抗体夹心法进行A组轮状病毒(RV)抗原检测,并比较分析检测数据。结果 2 164份腹泻标本有684份RV阳性,总阳性率为31.61%,其中男性阳性率为31.07%、女性阳性率为32.37%,两者阳性率差异无统计学意义;6月龄~1岁腹泻患者阳性率可高达38.74%,占55.56%,1~2岁腹泻患者阳性率31.92%,占14.33%,2~3岁腹泻患者阳性率33.73%,占8.19%;以每年秋冬季节10、11、12和1月份为发病高峰,占83.33%。结论轮状病毒是患者腹泻的主要病原体之一,男女患者阳性率差异无统计学意义,6月龄~3岁患者是轮状病毒的易感人群,以秋冬季节为RV流行高峰。
[Abstract]:Objective to investigate the relationship between rotavirus (RV) infection and sex, age, season and infection rate of RV in patients with diarrhea in Guangzhou area, and to provide reliable experimental data for clinical diagnosis, treatment and prevention. Methods A group A rotavirus (RV) antigen was detected by immunochromatographic double antibody sandwich method in 2,164 fecal specimens from hospitalized and outpatients with diarrhea from January 2010 to December 2012, and the data were compared and analyzed. Results among the 2 164 diarrhea specimens, 684 were RV positive, the total positive rate was 31.61. The positive rate of male was 31.07 and that of female was 32.37. There was no significant difference between them. The positive rate of diarrhea patients aged from 6 months to 1 year old can be as high as 38.74, accounting for 31.92% of the patients with diarrhea at 55.56 and 1 year old, and 31.92% of the patients with diarrhea at the age of 14.333.The positive rate is 33.73, accounting for 8.19%. In autumn and winter, the incidence rate was 83.33 in January and 101.12 in autumn and winter. Conclusion rotavirus is one of the main pathogens of diarrhea in patients. There is no significant difference in positive rate between male and female patients. Patients aged from 6 months to 3 years old are susceptible to rotavirus, and autumn and winter seasons are the peak of RV epidemic.
【作者单位】：广州医科大学附属第二医院检验科;
【基金】：广东省医学科研基金资助项目(A2012256)
【分类号】：R512.5

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