河南省开封市育龄妇女与婴儿麻疹抗体水平调查分析

发布时间：2018-11-22 15:13

【摘要】：目的了解河南省开封市育龄妇女与婴儿麻疹抗体水平,探寻高发人群麻疹免疫预防策略。方法采用酶联免疫吸附试验(ELISA)对开封市育龄妇女与婴儿进行麻疹IgG抗体水平血清学检测和统计学分析。结果 740名婴儿中麻疹IgG抗体阳性率为45.00%,抗体保护率为22.57%,抗体几何平均浓度(GMC)为91.34IU/ml。8~11月龄婴儿麻疹抗体GMC高于0~7月龄婴儿(t=5.16,P0.01)。0~7月龄婴儿麻疹抗体阳性率随着月龄增大而降低(χ~2=136.51,P0.01),7月龄组婴儿抗体水平最低,GMC为17.41 IU/ml;而8~11月龄婴儿抗体阳性率随着月龄的增长而上升(χ~2=49.53,P0.01);有含麻疹成分疫苗(MCV)免疫史婴儿抗体水平高于无免疫史(t=9.24,P0.01)。249名育龄妇女麻疹抗体阳性率为94.38%,抗体保护率为50.20%,GMC为694.54IU/ml;29~35岁组抗体GMC高于18~28岁组(t=5.47,P0.01);有免疫史者抗体GMC低于无免疫史者(t=6.76,P0.01);有患病史者抗体GMC高于无患病史者(t=13.42,P0.01)。结论育龄妇女、婴儿麻疹抗体水平低,需通过提高首剂MCV及时接种率、实时调整首剂MCV接种月龄及育龄妇女接种等综合免疫预防措施来推进消除麻疹工作。
[Abstract]:Objective to investigate the measles antibody level among childbearing women and infants in Kaifeng City, Henan Province, and to explore the strategy of measles immunization prevention in high incidence population. Methods Elisa (ELISA) was used to detect measles IgG antibody level in childbearing women and infants in Kaifeng city. Results among 740 infants, the positive rate of measles IgG antibody was 45.00, and the protective rate of measles antibody was 22.57. The geometric mean concentration of (GMC) of measles antibody GMC of 91.34IU/ml.8~11 month-old infants was higher than that of 0-7-month-old infants (t = 5.16). The positive rate of measles antibody in 7-month-old infants decreased with the increase of age (蠂 ~ (2) 136.51 / P0.01). The antibody level of infants in 7-month-old group was the lowest (GMC = 17.41 IU/ml;). However, the positive rate of antibody increased with the increase of age (蠂 ~ 2 + 49.53 / P0.01). The antibody level of infants immunized with measles vaccine was higher than that without immunization history (t 9.24 P0.01). The positive rate of measles antibody in 249 women of childbearing age was 94.38, and the protective rate of antibody was 50.20%. The antibody GMC in the age group of 29 ~ 35 years was higher than that in the group of 18 ~ 28 years old (t = 5.47, P0.01), the antibody GMC in the group with immunological history was lower than that in the group without immune history (t = 6.76, P 0.01), and the antibody GMC in those with a history of disease was higher than that in the group without a history of disease (t = 13.42, P 0.01). Conclusion the level of measles antibody in infants of childbearing age women is low. It is necessary to improve the vaccination rate of first dose of MCV in time and to adjust the first dose of MCV vaccination in real time to promote the work of eliminating measles by means of comprehensive immunization prevention measures such as inoculation of the first dose of MCV and inoculation of women of childbearing age.
【作者单位】：河南省开封市疾病预防控制中心;河南大学第一附属医院;
【基金】：开封市科技发展计划项目(项目号130332)
【分类号】：R511.1

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