安徽省2011-2012年报告HIV-1新发感染者流行病学特征分析
发布时间：2018-11-25 22:07
【摘要】：目的应用BED捕获酶免疫实验（BED capture enzyme immunoassay, BED-CEIA）的检测方法对HIV-1感染者进行新发感染检测，并对安徽省HIV-1新发感染者情况及患者特征进行分析，从而来确定各种特征和因素与新发感染的相关性。 方法收集2011年7月至2012年6月安徽省全省各艾滋病确证实验室新确证HIV-1型感染者血清/血浆，进行BED-CEIA检测；再通过对艾滋病综合防治信息系统中各级疾病预防控制机构对艾滋病病毒感染者进行的个案流行病学资料进行分析，，评估新发感染情况并分析其患者特征；同时对2011年和2012年安徽省男男性行为者（Men who have sex with men, MSM）哨点初筛阳性样本，进行HIV确证实验，确证阳性样本再进行新发感染检测，以此来估算出此类高危人群的新发感染率。 结果2011年7月至2012年6月安徽省新报告HIV感染者748例，通过BED-CEIA方法检测出184例为新近感染，HIV-1感染者新发感染比例为24.6%；通过对新近感染者与既往感染者特征的比较，新发感染者中，男性、农民、MSM以及医院就诊者比例较高。与既往感染患者相比，新近感染者年龄更轻，且男性所占比例以及男男同性性行为者的比例均较高，并伴有更高的CD4细胞数，而农民在新近感染者中的比例有所降低；对2011和2012年安徽省MSM哨点初筛阳性样本进行蛋白印迹法（Western blot, WB）确证实验，分别检测出新发感染例数为8例和18例，再采用Hargrove法中点公式计算MSM人群新发感染率分别为5.53%和3.95%。结论通过BED检测方法估算出安徽省2011-2012年HIV-1新报告感染者新发感染比例较高，再通过对高危人群的分析发现男男同性性行为是新发感染的主要风险因素，且MSM哨点新发感染率较高与病例报告的新发感染中男男同性传播因素高度相关情况相吻合，为科学的评估艾滋病流行趋势、确定监测方案和针对高危人群制定合理的防控措施提供更多的依据。
[Abstract]:Objective to detect the new infection of HIV-1 infected by BED capture enzyme immunoassay (BED capture enzyme immunoassay, BED-CEIA), and to analyze the status and characteristics of HIV-1 infection in Anhui province. To determine the characteristics and factors associated with new infections. Methods from July 2011 to June 2012, the serum / plasma of newly confirmed HIV-1 patients in Anhui Province were collected and tested for BED-CEIA. Then through the analysis of the case epidemiological data of HIV infection by the disease prevention and control agencies at all levels in the comprehensive AIDS prevention and control information system, the new infection situation and the characteristics of the patients were evaluated. At the same time, the positive samples of (Men who have sex with men, MSM) sentinel spot in Anhui Province in 2011 and 2012 were tested by HIV confirmatory test, and the positive samples were tested for new infection. This is used to estimate the incidence of new infections in such high-risk groups. Results from July 2011 to June 2012, 748 new cases of HIV infection were reported in Anhui province. 184 cases were newly infected by BED-CEIA, and the rate of new infection of HIV-1 infection was 24.6; By comparing the characteristics of newly infected persons with those of previous infections, the proportion of newly infected men, farmers, MSM and hospital patients was higher. Compared with the patients with previous infection, the newly infected patients were younger, the proportion of men and men who had sex with men were higher and the number of CD4 cells was higher, but the proportion of farmers in newly infected patients was lower. The positive samples of MSM sentinel screening in Anhui Province in 2011 and 2012 were confirmed by Western blot (Western blot, WB). The number of new infections was 8 cases and 18 cases, respectively. The new infection rate of MSM was 5.53% and 3.95% respectively by using the midpoint formula of Hargrove method. Conclusion it is estimated by BED test that the proportion of newly reported new infections of HIV-1 in Anhui Province from 2011 to 2012 is high, and the analysis of high risk population shows that male homosexual sex is the main risk factor of new infection. Moreover, the high rate of new infection in MSM sentinel site coincided with the high correlation between male and male homosexual transmission factors in the newly reported cases, which is a scientific assessment of the trend of AIDS epidemic. To determine the monitoring program and to establish reasonable prevention and control measures for high-risk groups to provide more basis.
【学位授予单位】：安徽医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R512.91
本文编号：2357505
[Abstract]:Objective to detect the new infection of HIV-1 infected by BED capture enzyme immunoassay (BED capture enzyme immunoassay, BED-CEIA), and to analyze the status and characteristics of HIV-1 infection in Anhui province. To determine the characteristics and factors associated with new infections. Methods from July 2011 to June 2012, the serum / plasma of newly confirmed HIV-1 patients in Anhui Province were collected and tested for BED-CEIA. Then through the analysis of the case epidemiological data of HIV infection by the disease prevention and control agencies at all levels in the comprehensive AIDS prevention and control information system, the new infection situation and the characteristics of the patients were evaluated. At the same time, the positive samples of (Men who have sex with men, MSM) sentinel spot in Anhui Province in 2011 and 2012 were tested by HIV confirmatory test, and the positive samples were tested for new infection. This is used to estimate the incidence of new infections in such high-risk groups. Results from July 2011 to June 2012, 748 new cases of HIV infection were reported in Anhui province. 184 cases were newly infected by BED-CEIA, and the rate of new infection of HIV-1 infection was 24.6; By comparing the characteristics of newly infected persons with those of previous infections, the proportion of newly infected men, farmers, MSM and hospital patients was higher. Compared with the patients with previous infection, the newly infected patients were younger, the proportion of men and men who had sex with men were higher and the number of CD4 cells was higher, but the proportion of farmers in newly infected patients was lower. The positive samples of MSM sentinel screening in Anhui Province in 2011 and 2012 were confirmed by Western blot (Western blot, WB). The number of new infections was 8 cases and 18 cases, respectively. The new infection rate of MSM was 5.53% and 3.95% respectively by using the midpoint formula of Hargrove method. Conclusion it is estimated by BED test that the proportion of newly reported new infections of HIV-1 in Anhui Province from 2011 to 2012 is high, and the analysis of high risk population shows that male homosexual sex is the main risk factor of new infection. Moreover, the high rate of new infection in MSM sentinel site coincided with the high correlation between male and male homosexual transmission factors in the newly reported cases, which is a scientific assessment of the trend of AIDS epidemic. To determine the monitoring program and to establish reasonable prevention and control measures for high-risk groups to provide more basis.
【学位授予单位】：安徽医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R512.91
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本文编号：2357505
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