伏立康唑治疗严重烧伤患者真菌感染临床疗效分析

发布时间：2018-11-28 15:38

【摘要】：目的探讨伏立康唑治疗严重烧伤并发真菌感染临床效果及安全性,为临床治疗提供参考。方法选择2012年1月-2014年12月48例严重烧伤并发真菌感染患者,按照数字表法分为对照组与观察组,对照组22例使用氟康唑治疗,观察组26例使用伏立康唑治疗;分析患者临床特征,对比两组患者治疗后临床效果及不良反应。结果 48例患者拟诊30例、16例患者确诊,共检出真菌24株,白色假丝酵母菌12株、曲霉菌属6株;观察组治疗有效率80.77%,明显高于对照组的68.18%,两组差异有统计学意义(χ2=5.978,P0.01);观察组并发症发生率15.38%,低于对照组,两组比较差异有统计学意义(χ2=7.383,P0.01);两组患者降钙素原、C-反应蛋白治疗后相比治疗前均有显著改善(P0.05);观察组降钙素原、C-反应蛋治疗后相比对照组改善更明显(P0.05)。结论伏立康唑治疗严重烧伤并发真菌感染临床效果显著,不良反应少,值得临床推广应用。
[Abstract]:Objective to investigate the efficacy and safety of fulconazole in the treatment of severe burn complicated with fungal infection. Methods from January 2012 to December 2014, 48 patients with severe burn complicated with fungal infection were divided into control group and observation group according to digital table method. 22 cases in control group were treated with fluconazole, 26 cases in observation group were treated with fulconazole. The clinical characteristics of the patients were analyzed and the clinical effects and adverse reactions were compared between the two groups. Results among the 48 patients, 30 were diagnosed and 16 were diagnosed. 24 strains of fungi, 12 strains of Candida albicans and 6 strains of Aspergillus were detected. The effective rate of treatment in the observation group was 80.77, which was significantly higher than that in the control group (68.18%). The difference between the two groups was statistically significant (蠂 2, 5.978, P 0.01). The incidence of complications in the observation group was 15.38, which was lower than that in the control group, and the difference between the two groups was statistically significant (蠂 2, 7.383, P0.01), and there was significant improvement in the two groups after the treatment of procalcitonin and C-reactive protein (P0.05). The treatment of procalcitonin and C-reactive egg in the observation group was better than that in the control group (P0.05). Conclusion the efficacy of fulconazole in treating severe burn complicated with fungal infection is significant, and its adverse reaction is less, so it is worth popularizing.
【作者单位】：深圳市宝安区人民医院烧伤整形外科;
【基金】：深圳市科技局基金资助项目(201103070)
【分类号】：R644;R519

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