50例先天性梅毒新生儿的临床分析

发布时间：2018-12-17 05:02

【摘要】：目的探讨天性梅毒新生儿的临床表现、诊断情况、治疗方法和预后。方法回顾性分析我院2013年1月~2015年6月收治的50例天性梅毒新生儿的临床资料。结果天性梅毒新生儿的临床表现多为皮肤粘膜受损、黄疸、肝损害、肝脾肿大等;临床诊断以血球凝集反应侦测梅毒螺旋体抗体(TPHA)和快速血浆反应素试验(RPR)的检测结果均为阳性即可确诊为先天性梅毒新生儿;本次实验使用青霉素治疗先天性梅毒新生儿,3例放弃治疗,47例接受治疗的患儿中痊愈45例,死亡2例;预后效果中,12个月复查的TPHA转阴率为47.62%,12个月复查的RPR转阴率为95.24%。结论若新生儿出现皮肤粘膜受损、黄疸、肝损害等症状应高度怀疑先天性梅毒,应及早进行诊断和治疗。
[Abstract]:Objective to investigate the clinical manifestation, diagnosis, treatment and prognosis of congenital syphilis neonates. Methods the clinical data of 50 newborns with acquired syphilis admitted in our hospital from January 2013 to June 2015 were analyzed retrospectively. Results the clinical manifestations of congenital syphilis neonates were mostly skin mucosa damage, jaundice, liver damage, hepatosplenomegaly and so on. Congenital syphilis newborns can be diagnosed as congenital syphilis by hemagglutination reaction (HCR) detection of Treponema pallidum antibody (TPHA) and rapid plasma reactive hormone test (RPR). In this experiment, penicillin was used to treat congenital syphilis newborns, 3 cases gave up treatment, 45 cases were cured and 2 cases died. The negative rate of TPHA was 47.62 in 12 months and 95.24 in 12 months. Conclusion congenital syphilis should be highly suspected and diagnosed and treated as early as possible if the newborn has skin and mucous membrane damage, jaundice and liver damage.
【作者单位】：南京医科大学附属无锡人民医院新生儿科;
【分类号】：R759.15

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