阿苯达唑治疗囊型棘球蚴病疗效的Meta分析

发布时间：2018-12-17 10:40

【摘要】：目的:系统评价阿苯达唑治疗囊型棘球蚴病的疗效,为临床提供循证参考。方法:计算机检索Pub Med、EMBase、Cochrane图书馆、中国生物医学文献数据库、相关期刊论文、中文科技期刊数据库和万方数据库,收集阿苯达唑单药或联合其他阳性药物/外科手术治疗囊型棘球蚴病的随机对照试验(RCT),对符合纳入标准的研究提取资料并按照Cochrane协作网提供的偏倚风险评价工具5.1.0进行质量评价,采用Rev Man 5.3统计软件进行Meta分析。结果:共纳入11项RCT,合计1 020例患者。Meta分析结果显示,阿苯达唑单药治疗囊型棘球蚴病可以显著提高有效率[RR=4.08,95%CI(1.82,9.14),P0.001];阿苯达唑联合其他阳性药物的有效率显著高于阳性药物单用[RR=1.28,95%CI(1.01,1.63),P=0.04];阿苯达唑联合外科手术治疗的有效率显著高于单纯外科手术治疗[RR=1.22,95%CI(1.10,1.35),P0.001],差异均有统计学意义。结论:阿苯达唑单药或联合其他阳性药物/外科手术治疗囊型棘球蚴病疗效均较好。
[Abstract]:Objective: to evaluate the efficacy of albendazole in the treatment of cystic echinococcosis. Methods: Pub Med,EMBase,Cochrane library, Chinese biomedical literature database, Chinese periodical full-text database, Chinese sci-tech periodical database and Wanfang database were searched by computer. A randomized controlled trial (RCT),) of albendazole single or other positive drugs / surgery for the treatment of hydatid cyst The data were extracted according to the inclusion criteria and evaluated according to the bias risk assessment tool 5.1.0 provided by Cochrane Cooperative Network. The Meta analysis was carried out with Rev Man 5.3 statistical software. Results: a total of 1 020 patients with 11 items of RCT, were included. The results of Meta analysis showed that albendazole monotherapy could significantly improve the effective rate [RR=4.08,95%CI (1.82 9. 14), P0. 001]; The effective rate of albendazole combined with other positive drugs was significantly higher than that of the positive drug alone [RR=1.28,95%CI (1.01 卤1.63), P < 0.04]. The effective rate of albendazole combined surgery was significantly higher than that of simple surgical treatment [RR=1.22,95%CI (1.101.35), P0.001]. Conclusion: albendazole alone or in combination with other positive drugs / surgery is effective in the treatment of hydatidosis.
【作者单位】：四川大学华西药学院;四川大学华西第二医院药学部;四川大学华西第二医院循证药学中心;出生缺陷与相关妇儿疾病教育部重点实验室;西藏自治区人民医院药剂科;西藏自治区人民医院妇产科;
【基金】：国家科技支撑计划课题(No.2009BAI76B030920)
【分类号】：R532.32

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