丝裂霉素C在介入治疗结核性中心气道瘢痕狭窄中的作用

发布时间：2018-12-23 08:51

【摘要】：目的:探讨应用支气管镜局部喷洒丝裂霉素C(MMC)在治疗结核性中心气道瘢痕狭窄中的临床疗效。方法:将结核性中心气道瘢痕狭窄患者45例随机分为对照组(14例)、治疗1组(15例)和治疗2组(16例),分别进行常规球囊扩张、常规球囊扩张加局部喷洒1次MMC和2次MMC治疗,以治疗前、治疗结束时及治疗后3、6、12个月的MRC评分和气道直径为指标考察其临床疗效。结果:(1)各观察时间点的MRC评分:治疗后3个月治疗2组(0.06±0.25)与治疗1组(0.33±0.617)MRC评分均显著低于对照组(0.57±0.756)(均P0.05)。其他各时间点3组MRC评分差异均无显著性。(2)各观察时间点的气道直径:治疗后3、6个月治疗2组气道平均直径显著大于对照组与治疗1组(P0.01,P0.05);治疗后12个月治疗2组气道平均直径显著大于治疗1组(P0.05)。其他各时间点3组气道平均直径差异均无显著性(P0.05)。结论:球囊扩张术时局部喷洒MMC对改善结核性气道瘢痕狭窄患者呼吸困难症状、维持扩张后气道直径方面具有一定的近、远期临床疗效。
[Abstract]:Objective: to investigate the clinical effect of local spraying of mitomycin C (MMC) with bronchoscope in the treatment of tuberculous central airway scar stenosis. Methods: Forty-five patients with tuberculous central airway scar stenosis were randomly divided into control group (n = 14), treatment group (n = 15) and treatment group (n = 16). Routine balloon dilatation combined with local spraying of 1 MMC and 2 MMC were used to evaluate the clinical efficacy of MRC score and airway diameter before treatment, at the end of treatment and 3 months after treatment. Results: (1) the MRC score of each observation time point: the MRC score of treatment group (0.06 卤0.25) and treatment group 1 (0.06 卤0.25) was significantly lower than that of control group (0.57 卤0.756) 3 months after treatment (P0.05). There was no significant difference in MRC scores among the other three groups. (2) the airway diameter of each observation time point: the mean airway diameter of treatment group 3 months and 6 months after treatment was significantly larger than that of control group and treatment group 1 (P0.01P 0.05). At 12 months after treatment, the mean airway diameter of treatment group was significantly larger than that of treatment group 1 (P0.05). There was no significant difference in the mean airway diameter among the three groups at other time points (P0.05). Conclusion: local spraying of MMC during balloon dilatation can improve the symptoms of dyspnea and maintain the airway diameter after dilatation in patients with tuberculous airway scar stenosis.
【作者单位】： 广州市胸科医院;
【基金】：广东省科技厅计划项目(编号:2013B021800077) 广州市卫生局项目(编号:20121A011085)
【分类号】：R52

【参考文献】

相关期刊论文 前2条

1 方琼;谢艺开;李映文;彭德虎;谭毅刚;卢燕云;;支气管镜介入治疗结核性气道狭窄合并肺不张50例疗效分析[J];实用医学杂志;2013年19期

2 李阳轲;;经纤维支气管镜下注射异烟肼及丝裂霉素C治疗支气管结核及预防气道狭窄的研究[J];四川医学;2013年12期

【共引文献】

相关期刊论文 前2条

1 马艳莉;何元兵;齐曼古力·吾守尔;焦克岗;;联合介入方法治疗良性瘢痕增生性气道狭窄的疗效分析[J];临床肺科杂志;2014年10期

2 王晓洁;牛建明;李润浦;;支气管镜介入冷冻联合氩气刀治疗结核性大气道狭窄的疗效[J];检验医学与临床;2015年02期

【相似文献】

相关期刊论文 前2条

1 谢斌;殷敏;朱歆洁;林子萍;;丝裂霉素C在治疗气道瘢痕狭窄中的应用[J];临床耳鼻咽喉头颈外科杂志;2013年12期

2 ;[J];;年期

相关会议论文 前1条

1 王晓平;马秀丽;王锦艳;彭镜圆;万爱芳;毕耜宝;;经支气管镜球囊扩张冷冻序贯治疗结核性支气管狭窄效果评价[A];2011年中国防痨协会全国学术会议论文集[C];2011年

相关重要报纸文章 前1条

1 北京天坛医院呼吸科 张杰　王娟;结核性气道瘢痕狭窄可气管镜治疗[N];健康报;2009年

，

本文编号：2389727