支气管镜肺泡灌洗与抗真菌药物治疗肺部真菌感染临床分析

发布时间：2018-12-25 15:32

【摘要】：目的探讨纤维支气管镜(FB)灌洗与抗真菌药物治疗肺部真菌感染(PFI)的效果。方法 2011年1月-2012年7月收治的168例PFI患者分成灌洗组和对照组,灌洗组84例患者,接受FB灌洗治疗;对照组84例患者,接受常规抗真菌治疗,比较两组患者治疗效果,使用SPSS 17.0软件进行统计分析。结果患者治疗显效率、总有效率灌洗组为64.3%、90.5%,均高于对照组的38.1%、66.7%(P0.05);灌洗组总体疗效优于对照组,差异有统计学意义(P0.01);两组患者治疗后PaO2、PaCO2比较,差异有统计学意义(P0.01);灌洗组患者治疗后痰液真菌阴转率83.3%,高于对照组的61.9%(P0.05);灌洗组发热天数、住院时间均低于对照组;对照组病死率14.3%,高于灌洗组的2.4%(χ2=3.8961,P=0.0484)。结论 FB灌洗抗真菌药治疗PFI,可以提高有效率、缩短病程、减少并发症,综合效价比较高。
[Abstract]:Objective to investigate the effect of bronchofiberscope (FB) lavage and antifungal drugs on pulmonary fungal infection (PFI). Methods from January 2011 to July 2012, 168 patients with PFI were divided into lavage group (n = 84) and control group (n = 84). 84 patients in the control group were treated with routine antifungal therapy. The therapeutic effects of the two groups were compared. Statistical analysis was made with SPSS 17.0 software. Results the total effective rate in the lavage group was 90.5, which was higher than that in the control group (38.1%, P 0.05), the total effective rate in the lavage group was better than that in the control group (P 0.01). There was significant difference in PaO2,PaCO2 between the two groups after treatment (P0.01). The negative rate of sputum fungi in the lavage group was 83.3%, which was higher than that in the control group (61.9%) (P0.05). The days of fever and the length of hospitalization in the lavage group were lower than those in the control group, and the fatality rate in the control group was 14.3%, which was higher than that in the lavage group (蠂 ~ 2 3.8961P ~ (0.0484). Conclusion FB lavage antifungal drugs can improve the effective rate, shorten the course of disease and reduce the complications in the treatment of PFI, and the comprehensive titer is higher.
【作者单位】：宁波鄞州人民医院呼吸内科;宁波医学院;
【基金】：浙江省医药科技基金资助项目(2008GA011)
【分类号】：R519

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