脑脊液与血浆生化指标比值对结核性脑膜炎与化脓性脑膜炎的鉴别意义
发布时间：2018-12-26 10:18
【摘要】：目的探讨脑脊液(CSF)与血浆生化指标比值对结核性脑膜炎与化脓性脑膜炎的鉴别意义。方法选取2007年1月—2013年12月湖州市中心医院神经内科及感染科收治的结核性脑膜炎患者55例(结核性脑膜炎组),化脓性脑膜炎患者73例(化脓性脑膜炎组)。采集患者静脉血及CSF标本,测定其CSF及血浆糖、蛋白、腺苷脱氨酶(ADA)和氯化物含量,并计算CSF/血浆中上述生化指标的比值。结果两组CSF糖、蛋白含量比较,差异无统计学意义(P0.05);结核性脑膜炎组氯化物含量低于化脓性脑膜炎组,ADA含量高于化脓性脑膜炎组(P0.05)。两组血浆糖含量比较,差异无统计学意义(P0.05);结核性脑膜炎组蛋白、氯化物含量低于化脓性脑膜炎组,ADA含量高于化脓性脑膜炎组(P0.05)。两组CSF/血浆糖比值比较,差异无统计学意义(P0.05);结核性脑膜炎组蛋白比值、ADA比值高于化脓性脑膜炎组,氯化物比值低于化脓性脑膜炎组(P0.05)。绘制CSF/血浆ADA比值联合氯化物比值诊断结核性脑膜炎的ROC曲线,选取切点ADA比值≥1.19且氯化物比值≤0.93时,灵敏度为78.2%,特异度为78.1%,曲线下面积为0.836。结论 CSF中ADA、氯化物含量和CSF/血浆蛋白、ADA、氯化物比值在结核性脑膜炎中有特定意义,特别是CSF/血浆ADA比值≥1.19联合氯化物比值≤0.93时对结核性脑膜炎的诊断意义较大,有助于临床医生鉴别结核性脑膜炎和化脓性脑膜炎。
[Abstract]:Objective to study the value of (CSF) / plasma biochemical index ratio in differentiating tuberculous meningitis from suppurative meningitis. Methods from January 2007 to December 2013, 55 patients with tuberculous meningitis (tuberculous meningitis group) and 73 patients with suppurative meningitis (suppurative meningitis group) were selected from Department of Neurology and infection Department of Huzhou Central Hospital. The contents of CSF, plasma glucose, protein, adenosine deaminase (ADA) and chloride were measured in patients with CSF and venous blood samples, and the ratio of these biochemical indexes in plasma of CSF/ was calculated. Results there was no significant difference in the content of CSF sugar and protein between the two groups (P0.05), while the content of chloride in tuberculous meningitis group was lower than that in suppurative meningitis group, and the content of ADA in tuberculous meningitis group was higher than that in suppurative meningitis group (P0.05). There was no significant difference in plasma sugar content between the two groups (P0.05); the content of protein and chloride in tuberculous meningitis group was lower than that in suppurative meningitis group, and the content of ADA was higher than that in suppurative meningitis group (P0.05). There was no significant difference in plasma glucose ratio between the two groups (P0.05); the ratio of protein and ADA in tuberculous meningitis group was higher than that in suppurative meningitis group, and the chloride ratio was lower than that in suppurative meningitis group (P0.05). The ROC curve of CSF/ plasma ADA ratio combined with chloride ratio in the diagnosis of tuberculous meningitis was drawn. When the ADA ratio of the cut point 鈮，
本文编号：2391953
[Abstract]:Objective to study the value of (CSF) / plasma biochemical index ratio in differentiating tuberculous meningitis from suppurative meningitis. Methods from January 2007 to December 2013, 55 patients with tuberculous meningitis (tuberculous meningitis group) and 73 patients with suppurative meningitis (suppurative meningitis group) were selected from Department of Neurology and infection Department of Huzhou Central Hospital. The contents of CSF, plasma glucose, protein, adenosine deaminase (ADA) and chloride were measured in patients with CSF and venous blood samples, and the ratio of these biochemical indexes in plasma of CSF/ was calculated. Results there was no significant difference in the content of CSF sugar and protein between the two groups (P0.05), while the content of chloride in tuberculous meningitis group was lower than that in suppurative meningitis group, and the content of ADA in tuberculous meningitis group was higher than that in suppurative meningitis group (P0.05). There was no significant difference in plasma sugar content between the two groups (P0.05); the content of protein and chloride in tuberculous meningitis group was lower than that in suppurative meningitis group, and the content of ADA was higher than that in suppurative meningitis group (P0.05). There was no significant difference in plasma glucose ratio between the two groups (P0.05); the ratio of protein and ADA in tuberculous meningitis group was higher than that in suppurative meningitis group, and the chloride ratio was lower than that in suppurative meningitis group (P0.05). The ROC curve of CSF/ plasma ADA ratio combined with chloride ratio in the diagnosis of tuberculous meningitis was drawn. When the ADA ratio of the cut point 鈮，
本文编号：2391953
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