血清维生素D水平与肺结核发病关联性的探索分析

发布时间：2018-12-27 12:41

【摘要】：目的:探讨血清维生素D水平与肺结核发病之间的关系。方法:以人群调查为基础,选择70名新发初治菌阳肺结核患者为病例组,根据性别、年龄和居住地作为配对条件1:3纳入未患结核病的健康人群对照,对资料进行均数检验、条件Logistic回归分析,维生素D水平采用Roche Cobas e601型全自动电化学发光免疫分析仪进行检测。结果:共纳入70例肺结核患者与210例健康对照人群,病例组男性的血清维生素D水平明显高于对照组男性(P0.05),经条件Logistic回归分析也显示,血清维生素D是肺结核发病的危险因素(OR=1.04,95%CI:1.001~1.070,P0.05)。结论:血清维生素D与肺结核的患病风险具有统计学关联,对于维生素D在影响肺结核发病中的价值,仍需在国内人群中开展更多高质量、大样本的流行病学调查验证以提供更充分的证据。
[Abstract]:Objective: to investigate the relationship between serum vitamin D level and pulmonary tuberculosis. Methods: on the basis of population investigation, 70 patients with newly diagnosed bacillus positive pulmonary tuberculosis were selected as the case group. According to sex, age and place of residence as matched conditions, the healthy people without tuberculosis were included in the control group at 1:3, and the mean of the data was tested. Conditional Logistic regression analysis showed that vitamin D level was determined by Roche Cobas e 601 automatic electrochemiluminescence immunoanalyzer. Results: the serum vitamin D levels in 70 patients with pulmonary tuberculosis and 210 healthy controls were significantly higher in the case group than in the control group (P0.05). The results of conditional Logistic regression analysis also showed that the serum vitamin D level in the male patients was significantly higher than that in the control group (P0.05). Serum vitamin D is the risk factor of pulmonary tuberculosis (OR=1.04,95%CI:1.001~1.070,P0.05). Conclusion: the serum vitamin D is associated with the risk of pulmonary tuberculosis. The value of vitamin D in affecting the incidence of pulmonary tuberculosis still needs more high quality in the domestic population. Large samples of epidemiological evidence were tested to provide more sufficient evidence.
【作者单位】：湖北省疾病预防控制中心传染病防治研究所;中国疾病预防控制中心结核病预防控制中心;
【基金】：十二五国家科技重大专项(编号:2013ZX10003004-001-010) 湖北省卫生厅青年人才项目(编号:QJX2012-25) 湖北省医学领军人才项目(2013年10月批准)
【分类号】：R521

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