中国2016年麻疹风疹实验室网络运转分析

发布时间：2019-03-01 15:44

【摘要】：目的通过对中国(未包括香港、澳门特别行政区和台湾地区)2016年麻疹风疹实验室网络(Measles/rubella laboratory network,MRLN)运转状况的分析和评估,为中国消除麻疹和控制风疹提供实验室依据。方法采用描述流行病学方法分析2016年中国麻疹监测信息报告管理系统中的实验室数据和全国MRLN监测数据,评价中国MRLN运转的各项指标。结果 2016年全国报告监测病例69 288例,其中散发病例63 211例,散发病例的血清和病原学标本采集率分别为96.25%、48.27%。麻疹、风疹Ig M检测阳性率分别为34.46%(22 276/64 637)、5.71%(3 646/63 828)。麻疹、风疹病毒核酸检测阳性率分别为32.54%(8 580/26 368)、4.16%(1 081/26 005)。29个省级麻疹风疹实验室(Measles/rubella laboratory,MRL)共送检麻疹病毒2 461株,其中D8基因型3株、A基因型(疫苗相关株)10株、H_(1a)基因亚型(中国本土流行优势株)2 448株;17个省级MRL共送检风疹病毒126株,其中1E基因型6株、2B基因型120株。国家麻疹风疹实验室(National measles/rubella laboratory,NMRL)作为世界卫生组织(WHO)西太平洋区麻疹风疹参比实验室通过了2016年WHO的血清和分子职能考核;6个省级MRL通过了WHO专家组的现场认证;所有省级MRL通过了WHO和NMRL组织的血清职能考核。结论 2016年中国MRLN运转良好,为麻疹消除和风疹控制提供了强有力的实验室科技支撑。
[Abstract]:Objective to analyze and evaluate the operation of measles rubella laboratory network (Measles/rubella laboratory network,MRLN) in China (excluding Hong Kong, Macao Special Administrative region and Taiwan) in 2016. Provide laboratory basis for measles elimination and rubella control in China. Methods the laboratory data in China measles surveillance information report management system in 2016 and the MRLN surveillance data in China were analyzed by descriptive epidemiology method, and the indexes of MRLN operation in China were evaluated. Results 69,288 surveillance cases were reported in China in 2016, of which 63,211 were sporadic cases. The collection rate of serum and pathogenic specimens of sporadic cases was 96.25% and 48.27%, respectively. The positive rates of Ig M for measles and rubella were 34.46% (22 276? 64,637) and 5.71% (3 646? 63,828) respectively. The positive rates of measles and rubella virus nucleic acid detection were 32.54% (8 580 脳 26 368) and 4.16% (1 081 脳 26 005) respectively. A total of 2 461 measles virus strains were detected in 29 provincial measles rubella laboratories (Measles/rubella laboratory,MRL). Among them, 3 strains of genotype D8, 10 strains of genotype A (vaccine-related strain), 2 448 strains of H1a gene subtype (dominant strain of Chinese native epidemic); Seventeen provincial MRL isolates were tested for rubella virus, including 6 strains of genotype 1e and 120 strains of genotype 2B. The National measles rubella Laboratory (National measles/rubella laboratory,NMRL) passed the examination of serum and molecular function of WHO in 2016 as the reference laboratory of measles and rubella in the (WHO) West Pacific region of the World Health Organization (WHO). Six provincial MRL passed the on-the-spot certification of WHO expert group; all the provincial MRL passed the examination of serum function organized by WHO and NMRL. Conclusion MRLN is functioning well in China in 2016, which provides strong laboratory support for measles elimination and rubella control.
【作者单位】：中国疾病预防控制中心病毒病预防控制所国家卫生和计划生育委员会医学病毒学和病毒病重点实验室世界卫生组织西太平洋区麻疹参比实验室;
【基金】：国家自然科学基金课题(项目号:81371791) 麻疹疾控专项经费(2016年) 行使WHO西太区地区麻疹风疹参比实验室职能(2016年)
【分类号】：R511.1

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