沈阳部分地区肝活检病理S3和S4期患者临床资料回顾性分析
发布时间：2019-03-14 09:51
【摘要】：目的:对慢性HBV感染者符合病理学分期为S3和S4期者的临床资料进行对比性研究,以探讨纤维化程度与临床指标的关系。 方法:对292例慢性HBV感染者肝活检符合病理学分期为S3和S4期者的临床资料进行回顾性分析，比较不同年龄,病程以及HBVDNA水平与病理学诊断的关系，同时还比较病理学诊断与患者病史，临床生化检测值及影像学指标之间的关系。 结果:292例患者中病理诊断为S3期有140（47.9%）例，S4期为152（52.1%）例。从年龄分布来㩳40岁组中S3期比例高于S4期，≥40岁组中S3期比例低于S4期。从ALT水平来看，在S4期中，ALT水平在1~2倍正常值组比例最高，而在S3期中，ALT水平≤1.0倍正常值组比例最高。进一步多因素的分析显示：病程，，年龄，饮酒史，ALT，HBVDNA水平以及彩超检查肝表面光滑程度都与肝纤维化的进展有关。 结论:1.病程大于5年以上且ALT水平介于1~2倍正常值的患者，进行肝活检的临床意义更大。2.对于肝纤维化治疗前的评估应进行多因素分析，而非仅依据ALT水平。
[Abstract]:Aim: to compare the clinical data of patients with chronic HBV infection in accordance with the pathological stages S3 and S4 in order to explore the relationship between the degree of fibrosis and clinical indexes. Methods: the clinical data of liver biopsy from 292 patients with chronic HBV infection were retrospectively analyzed, and the relationship among different age, course of disease, HBVDNA level and pathological diagnosis was compared, and the pathological stage was S _ 3 and S _ 4 stages of liver biopsy in patients with chronic HBV infection were analyzed retrospectively. At the same time, the relationship between pathological diagnosis and patient history, clinical biochemical value and imaging index was also compared. Results: in 292 cases, 140 (47.9%) cases were diagnosed as S3 stage and 152 (52.1%) cases were at S4 stage. According to the age distribution, the proportion of S _ 3 stage in 40-year-old group was higher than that in S-4 stage, and that in 鈮
本文编号：2439872
[Abstract]:Aim: to compare the clinical data of patients with chronic HBV infection in accordance with the pathological stages S3 and S4 in order to explore the relationship between the degree of fibrosis and clinical indexes. Methods: the clinical data of liver biopsy from 292 patients with chronic HBV infection were retrospectively analyzed, and the relationship among different age, course of disease, HBVDNA level and pathological diagnosis was compared, and the pathological stage was S _ 3 and S _ 4 stages of liver biopsy in patients with chronic HBV infection were analyzed retrospectively. At the same time, the relationship between pathological diagnosis and patient history, clinical biochemical value and imaging index was also compared. Results: in 292 cases, 140 (47.9%) cases were diagnosed as S3 stage and 152 (52.1%) cases were at S4 stage. According to the age distribution, the proportion of S _ 3 stage in 40-year-old group was higher than that in S-4 stage, and that in 鈮
本文编号：2439872
本文链接：https://www.wllwen.com/yixuelunwen/chuanranbingxuelunwen/2439872.html
最近更新
教材专著
