AIDS病人脑脊液与血液HIVRNA病毒载量相关性及影响因素

发布时间：2019-03-27 19:31

【摘要】：目的研究分析艾滋病病人脑脊液与血液艾滋病病毒(HIV)核糖核酸(RNA)病毒载量的相关性及影响因素。方法对68例艾滋病病人脑脊液及血液中HIV RNA病毒载量检测结果以及相关影响因素进行回顾性分析。结果 68例病人中,脑脊液HIV RNA病毒载量Log值高于或等于血液HIV RNA病毒载量Log值的20例(29.4%),低于血液HIV RNA病毒载量Log值的,或与血液HIV RNA病毒载量均低于检测下限的48例(70.6%)。单因素Logistic回归分析结果显示,中枢神经系统感染、脑脊液压力、脑脊液蛋白水平是脑脊液高HIV RNA病毒载量的危险因素,脑脊液葡萄糖是脑脊液高HIV RNA病毒载量的保护因素。多因素Logistic回归分析结果显示,脑脊液葡萄糖具有统计学意义[P=0.019,比值比(OR)=0.455],是脑脊液高HIV RNA病毒载量的保护因素,在其他因素不变的情况下,脑脊液葡萄糖浓度升高1个单位(mmol/L),病人脑脊液HIV RNA病毒载量Log值不低于血HIV RNA病毒载量Log值的风险下降为原来的0.455倍。结论脑脊液葡萄糖是脑脊液高HIV RNA病毒载量的保护因素。
[Abstract]:Objective to study the relationship between cerebrospinal fluid (CSF) and blood (HIV) ribonucleic acid (RNA) viral load in AIDS patients and its influencing factors. Methods the results of HIV RNA viral load detection in cerebrospinal fluid and blood of 68 AIDS patients were analyzed retrospectively. Results among 68 patients, 20 cases (29.4%) whose CSF HIV RNA viral load was higher than or equal to the blood HIV RNA virus load (29.4%) were lower than the blood HIV RNA viral load log value. There were 48 cases (70.6%) whose HIV RNA viral load was lower than the lower detection limit (70.6%). Univariate Logistic regression analysis showed that central nervous system infection, cerebrospinal fluid pressure and cerebrospinal fluid protein level were the risk factors for high HIV RNA viral load in CSF, and CSF glucose was the protective factor of CSF high HIV RNA viral load. Multivariate Logistic regression analysis showed that CSF glucose had statistical significance [P = 0.019, ratio of (OR) = 0.455]. It was a protective factor of high HIV RNA viral load in cerebrospinal fluid, while other factors remained unchanged. When the glucose concentration in cerebrospinal fluid increased by one unit (mmol/L), the risk of HIV RNA virus load in CSF of patients not lower than that of blood HIV RNA virus load was 0.455 times higher than that of the original. Conclusion Cerebrospinal fluid glucose is a protective factor of high HIV RNA viral load in cerebrospinal fluid.
【作者单位】：感染病科国家临床重点专科首都医科大学附属北京地坛医院感染性疾病诊疗中心;
【分类号】：R512.91

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