乙型肝炎后肝硬化患者小肠细菌过度生长情况的研究
发布时间：2019-03-27 16:56
【摘要】：[目的]探讨乙型肝炎后肝硬化患者的小肠细菌过度生长(SIBO)情况,以及SIBO与其肝功能状况、HBV-DNA之间的关系。[方法]将42例乙型肝炎后肝硬化患者按肝功能Child-Pugh分级分为A级、B级、C级三组,并入选同期门诊体检的健康者20例作为健康对照组。通过葡萄糖氢呼气试验(GHBT)检测并比较分析各组SIBO情况,同时检测并比较分析肝硬化患者各组的HBV-DNA水平及其SIBO阳性率。[结果]肝硬化各组患者与健康对照组的SIBO阳性率及试餐后呼气氢浓度比较均差异有统计学意义(P0.05)。肝硬化患者的SIBO阳性率及试餐后呼气氢浓度均随着Child-Pugh分级低下而呈渐进性增高,各组间差异有统计学意义(P0.05)。肝硬化患者各组间的SIBO阳性率及试餐后呼气氢浓度比较,HBV-DNA10~3时均明显高于HBV-DNA≤10~3时,且差异有统计学意义(P0.05)。[结论]乙型肝炎后肝硬化患者常存在SIBO,且随着肝功能恶化、HBV-DNA拷贝数增加,其SIBO加重,由此推测防治SIBO,可能对乙型肝炎后肝硬化患者的肝功能改善、乙肝病毒清除有益。
[Abstract]:[Objective] To study the intestinal bacterial overgrowth (SIBO) in patients with liver cirrhosis after hepatitis B and the relationship between SIBO and its liver function and HBV-DNA. [Methods] 42 patients with liver cirrhosis were divided into three groups: A, B and C according to Child-Pugh of liver function. The serum levels of HBV-DNA and the positive rate of SIBO in each group of patients with liver cirrhosis were detected and compared by a glucose-hydrogen-exhale test (GHBT). [Results] The positive rate of SIBO in the patients with liver cirrhosis and the healthy control group were significantly different from those in the healthy control group (P <0.05). The positive rate of SIBO in patients with liver cirrhosis and the concentration of expiratory hydrogen in the post-meal were increased with the low grade of Child-Pugh, and there was a significant difference among the groups (P <0.05). The positive rate of SIBO in patients with liver cirrhosis was significantly higher than that of HBV-DNA (10-3), and the difference was statistically significant (P0.05). [Conclusion] SIBO is often present in the patients with liver cirrhosis after hepatitis B, and with the deterioration of the liver function, the number of HBV-DNA copies is increased, and the SIBO of the patients with liver cirrhosis is increased, so it is presumed that the prevention and control of SIBO may be beneficial to the improvement of liver function and the elimination of hepatitis B virus in the patients with liver cirrhosis after hepatitis B.
【作者单位】： 解放军第169医院湖南师范大学附属湘南医院消化内科;
【分类号】：R512.62;R575.2
，
本文编号：2448369
[Abstract]:[Objective] To study the intestinal bacterial overgrowth (SIBO) in patients with liver cirrhosis after hepatitis B and the relationship between SIBO and its liver function and HBV-DNA. [Methods] 42 patients with liver cirrhosis were divided into three groups: A, B and C according to Child-Pugh of liver function. The serum levels of HBV-DNA and the positive rate of SIBO in each group of patients with liver cirrhosis were detected and compared by a glucose-hydrogen-exhale test (GHBT). [Results] The positive rate of SIBO in the patients with liver cirrhosis and the healthy control group were significantly different from those in the healthy control group (P <0.05). The positive rate of SIBO in patients with liver cirrhosis and the concentration of expiratory hydrogen in the post-meal were increased with the low grade of Child-Pugh, and there was a significant difference among the groups (P <0.05). The positive rate of SIBO in patients with liver cirrhosis was significantly higher than that of HBV-DNA (10-3), and the difference was statistically significant (P0.05). [Conclusion] SIBO is often present in the patients with liver cirrhosis after hepatitis B, and with the deterioration of the liver function, the number of HBV-DNA copies is increased, and the SIBO of the patients with liver cirrhosis is increased, so it is presumed that the prevention and control of SIBO may be beneficial to the improvement of liver function and the elimination of hepatitis B virus in the patients with liver cirrhosis after hepatitis B.
【作者单位】： 解放军第169医院湖南师范大学附属湘南医院消化内科;
【分类号】：R512.62;R575.2
，
本文编号：2448369
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