河南省2004～2015年疫苗相关麻痹型脊髓灰质炎病例分析
发布时间：2019-03-30 22:31
【摘要】：目的分析河南省口服脊髓灰质炎(脊灰)减毒活疫苗(OPV)接种后疫苗相关麻痹型脊灰(Vaccine-associated Paralytic Poliomyelitis,VAPP)病例发生规律,为其防控措施制定提供科学依据。方法采用描述性分析方法对河南省2004~2015年VAPP病例进行分析。结果 2004~2015年河南省共报告VAPP病例26例,发生率为0.16/100万剂次;其中首剂OPV接种后VAPP 20例(73.08%),发生率为1.11/100万剂次。发生数男女性比为5.5∶1。23例(88.46%)为2~6月龄儿童。接种至麻痹平均时间间隔为23天。病例麻痹部位主要为双下肢、单下肢。麻痹60天后随访均有残留麻痹。14例(53.85%)病例合并其他疾病,其中9例合并肛周脓肿。在13例脊灰疫苗病毒分离阳性的VAPP病例中,Ⅱ型占61.54%。结论 VAPP病例以低月龄、首剂OPV接种儿童为主。应密切关注脊灰疫苗免疫策略调整后VAPP发生情况。
[Abstract]:Aim to analyze the occurrence regularity of vaccine-related paralytic poliomyelitis (Vaccine-associated Paralytic Poliomyelitis,VAPP) cases after oral poliomyelitis (poliomyelitis) live attenuated vaccine (OPV) vaccination in Henan Province, and to provide scientific basis for its prevention and control measures. Methods descriptive analysis was used to analyze the cases of VAPP in Henan Province from 2004 to 2015. Results from 2004 to 2015, 26 cases of VAPP were reported in Henan province, the incidence rate was 0.16 / 1 million doses, among them 20 cases (73.08%) were VAPP after the first dose of OPV, the incidence rate was 1.11 / 1 million dose times. The ratio of male to female was 5.5% (88.46%). The average interval between vaccination and paralysis was 23 days. The paralysis site is mainly lower extremities, single lower extremities. 14 cases (53.85%) were complicated with other diseases, among which 9 cases were complicated with perianal abscess. Among 13 VAPP cases with positive poliovirus isolation, type 鈪，
本文编号：2450549
[Abstract]:Aim to analyze the occurrence regularity of vaccine-related paralytic poliomyelitis (Vaccine-associated Paralytic Poliomyelitis,VAPP) cases after oral poliomyelitis (poliomyelitis) live attenuated vaccine (OPV) vaccination in Henan Province, and to provide scientific basis for its prevention and control measures. Methods descriptive analysis was used to analyze the cases of VAPP in Henan Province from 2004 to 2015. Results from 2004 to 2015, 26 cases of VAPP were reported in Henan province, the incidence rate was 0.16 / 1 million doses, among them 20 cases (73.08%) were VAPP after the first dose of OPV, the incidence rate was 1.11 / 1 million dose times. The ratio of male to female was 5.5% (88.46%). The average interval between vaccination and paralysis was 23 days. The paralysis site is mainly lower extremities, single lower extremities. 14 cases (53.85%) were complicated with other diseases, among which 9 cases were complicated with perianal abscess. Among 13 VAPP cases with positive poliovirus isolation, type 鈪，
本文编号：2450549
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