柳胺酚及其新型衍生物YZ51通过靶向RRM2抑制HBV复制的作用及机制
发布时间：2019-04-24 18:28
【摘要】：正目的:研究核糖核苷酸还原酶(RR)作为抗HBV及其相关肝癌药物靶点的可能性以及其抑制剂抗HBV的作用和机制。方法:免疫印迹检测RR表达,RR assay检测其活性;虚拟筛选得到老药柳胺酚,并检测其对RR活性的抑制;PCR检测柳胺酚
[Abstract]:Aim: to study the possibility of ribonucleotide reductase (RR) as a target of anti-HBV and its related drugs for hepatocellular carcinoma (HCC) and the anti-HBV effect and mechanism of its inhibitor. Methods: immunoblotting was used to detect the expression of RR, RR assay to detect its activity; virtual screening was performed to obtain the old drug salicamol and its inhibition on RR activity was detected; PCR was used to detect the activity of salicylaminophenol.
【作者单位】： 浙江大学医学院病理与病理生理学教研室;
【分类号】：R512.62;R735.7
本文编号：2464682
[Abstract]:Aim: to study the possibility of ribonucleotide reductase (RR) as a target of anti-HBV and its related drugs for hepatocellular carcinoma (HCC) and the anti-HBV effect and mechanism of its inhibitor. Methods: immunoblotting was used to detect the expression of RR, RR assay to detect its activity; virtual screening was performed to obtain the old drug salicamol and its inhibition on RR activity was detected; PCR was used to detect the activity of salicylaminophenol.
【作者单位】： 浙江大学医学院病理与病理生理学教研室;
【分类号】：R512.62;R735.7
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