阿德福韦酯片与拉米夫定片治疗老年慢性乙肝患者的远期疗效

发布时间：2019-04-29 12:33

【摘要】：目的比较阿德福韦酯片与拉米夫定片治疗老年慢性乙肝患者的远期疗效。方法回顾性分析2010年3月至2012年3月该院收治的80例老年慢性乙肝患者的临床资料,依据随机数字表法分为研究组和对照组各40例。研究组给予阿德福韦酯片治疗;对照组给予拉米夫定片,所有患者均治疗4个疗程并随访1年。对比两组不同时段肝功能指标复常率、血病毒量转阴率、乙肝E抗原(HBe Ag)转阴率、粒细胞降低率及乙肝病毒脱氧核糖核酸(HBV-DNA)水平抑制率,并对比两组治疗期间不良反应情况。结果治疗第6、12、18、24个月和停药1年后,研究组患者肝功能指标复常率、血病毒量转阴率、HBe Ag转阴率均显著高于对照组同期(P0.05),但两组患者粒细胞降低率无统计学差异(P0.05);治疗第6、12、18、24个月研究组患者HBV-DNA水平总抑制率均高于对照组同期(P0.05);治疗过程中两组患者均没有发生显著的不良反应,血糖、甲胎蛋白等指标未发生显著异常。结论阿德福韦酯片治疗老年慢性乙肝患者较拉米夫定片的远期疗效更显著,能有效抑制HBV-DNA水平且安全性高。
[Abstract]:Objective to compare the long-term efficacy of adefovir and lamivudine in the treatment of elderly patients with chronic hepatitis B. Methods the clinical data of 80 elderly patients with chronic hepatitis B from March 2010 to March 2012 were retrospectively analyzed and divided into study group (n = 40) and control group (n = 40). Patients in the study group were treated with adefovir tablets and lamivudine tablets in the control group. All patients were treated for 4 courses and followed up for 1 year. The normalization rate of liver function index, the negative rate of blood virus volume, the negative rate of hepatitis B E antigen (HBe Ag), the reduction rate of granulocyte and the inhibition rate of hepatitis B virus deoxyribonucleic acid (HBV-DNA) level were compared between the two groups at different time points. The adverse reactions were compared between the two groups during treatment. Results after 6, 12, 18, 24 months of treatment and 1 year after withdrawal, the rate of liver function index normalization and the rate of, HBe Ag turning negative in blood volume in the study group were significantly higher than those in the control group (P0.05), and that in the study group was significantly higher than that in the control group (P0.05). But there was no significant difference between the two groups in the reduction rate of granulocyte (P0.05). The total inhibition rate of HBV-DNA level in the study group was higher than that in the control group at 6,12,18,24 months after treatment (P0.05), and no significant adverse reactions, blood glucose, alpha-fetoprotein and other indexes were found in the two groups during the treatment. Conclusion the long-term efficacy of adefovir dimethoate in the treatment of elderly patients with chronic hepatitis B is more significant than lamivudine. It can effectively inhibit the level of HBV-DNA and is safe.
【作者单位】：山东省费县人民医院感染科;山东省费县人民医院检验科;
【分类号】：R512.62

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