T-SPOT.TB联合ADA和TB-DNA在诊断结核性胸膜炎中的应用价值

发布时间：2019-05-10 21:39

【摘要】：目的探讨结核感染T细胞斑点试验(T-SPOT.TB)技术联合胸水腺苷脱氨酶(ADA)和痰液结核杆菌(TB-DNA)测定对结核性胸膜炎的定性诊断,以达到早期诊断的目的。方法选取唐都医院2014年7月-2015年12月收治的86例结核性胸膜炎患者作为试验组,80例非结核性胸膜炎患者作为对照组,均行T-SPOT.TB检测,同时联合检查患者胸水ADA和痰液TB-DNA,比较T-SPOT.TB、ADA和TB-DNA检测与三者联合检测的应用价值。结果 86例结核性胸膜炎患者,T-SPOT.TB阳性率为84.88%(73/86),ADA阳性率为53.48%(46/86),痰液TB-DNA阳性率为31.40%(27/86),三者联合检测阳性率为93.02%(80/86)。结论 T-SPOT.TB检测联合ADA和痰液TB-DNA检测对结核性胸膜炎的诊断有较高的敏感性,对疑似结核性胸膜炎患者的快速、准确诊断具有重要的辅助诊断价值。
[Abstract]:Objective to investigate the qualitative diagnosis of tuberculosis pleurisy by T cell dot test (T-SPOT.TB) combined with adenosine deaminase (ADA) and sputum tuberculosis bacillus (TB-DNA) in order to achieve the purpose of early diagnosis. Methods 86 patients with tuberculous pleurisy treated in Tangdu Hospital from July 2014 to December 2015 were selected as test group and 80 patients with non-tuberculous pleurisy as control group. T-SPOT.TB was detected in all patients. At the same time, the value of combined examination of pleural fluid ADA and sputum TB-DNA, was compared with that of TSPOT. TB.Ada and TB-DNA and the combined detection of TSPOT. TB, ADA and TB-DNA. Results in 86 patients with tuberculosis pleurisy, the positive rate of T-SPOT.TB was 84.88% (73 鈮，

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