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T细胞酶联免疫斑点法诊断结核性脑膜炎的Meta分析

发布时间:2019-06-11 10:32
【摘要】:目的探讨脑脊液和外周血T细胞酶联免疫斑点法(T-SPOT.TB)检测在结核性脑膜炎中的诊断价值。方法检索1990年1月至2013年10月PubMed、EMBASE等数据库,收集以T-SPOT.TB法诊断结核性脑膜炎的文献。由两位研究者独立筛选文献,提取资料,质量评价,以Meta-Disc 1.4软件进行Meta分析。结果共纳入8篇文献,425个病例,结核性脑膜炎232例。外周血组合并灵敏度为80%(95%CI:0.74~0.85),合并特异度为74%(95%CI:0.67~0.80),SROC曲线下面积为0.858 7;诊断比值比为15.50。脑脊液组合并灵敏度为76%(95%CI:0.70~0.82),合并特异度为83%(95%CI:0.77~0.88),SROC曲线下面积为0.892 7;合并诊断比值比为22.62。结论采用T-SPOT.TB法有助于提高结核性脑膜炎的诊断率。脑脊液T-SPOT.TB诊断准确性可能高于外周血组。
[Abstract]:Objective to evaluate the diagnostic value of cerebrospinal fluid (cerebrospinal fluid) and peripheral blood T cell enzyme linked immunosorbent assay (T-SPOT.TB) in tuberculosis meningitis. Methods from January 1990 to October 2013, PubMed,EMBASE and other databases were searched, and the literature on the diagnosis of tuberculosis meningitis by T-SPOT.TB method was collected. The literature was screened independently by the two researchers, the data were extracted and the quality was evaluated. Meta analysis was carried out with Meta-Disc 1.4 software. Results A total of 8 articles, 425 cases and 232 cases of tuberculosis meningitis were included. In the peripheral blood group, the sensitivity was 80% (95%CI:0.74~0.85), the combined specificity was 74% (the area under the 95%CI:0.67~0.80), SROC curve was 0.858, and the diagnostic ratio was 15.50). The sensitivity of cerebrospinal fluid combination was 76% (95%CI:0.70~0.82), the combined specificity was 83% (the area under 95%CI:0.77~0.88), SROC curve was 0.892), and the ratio of diagnosis to diagnosis was 22.62%. Conclusion T-SPOT.TB method is helpful to improve the diagnosis rate of tuberculosis meningitis. The diagnostic accuracy of cerebrospinal fluid T-SPOT.TB may be higher than that of peripheral blood group.
【作者单位】: 重庆医科大学附属第一医院感染科/教育部国家重点学科;
【分类号】:R529.3

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