结核病患者中性粒细胞L选择素的表达及意义
发布时间：2019-06-11 12:42
【摘要】：目的检测结核病患者外周血中性粒细胞(PMN)体外感染结核分枝杆菌(M.tb)前后L选择素(CD62L)的表达情况,并探讨CD62L在结核病的发展过程中的作用。方法应用流式细胞术检测结核病患者PMN表面CD62L的表达,同时检测正常人PMN的CD62L表达率;体外感染M.tb后,再检测结核病患者和正常人PMN的CD62L表达率。结果结核病患者PMN表面高表达CD62L,与正常人PMN表面CD62L表达无明显差异;感染M.tb后,结核病患者和正常人PMN表面CD62L表达率显著降低(P0.05)。结论结核病患者PMN表面CD62L参与了PMN的趋化过程,在结核炎症反应中发挥重要作用,推动结核病的发展过程。
[Abstract]:Objective To detect the expression of L-selectin (CD62L) in the peripheral blood of patients with tuberculosis (PM62L) and to explore the role of CD62L in the development of tuberculosis. Methods The expression of CD62L in PMN was detected by flow cytometry, and the expression rate of CD62L in normal human PMN was detected. Results The expression of CD62L on PMN surface in patients with tuberculosis was not significantly different from that of normal human PMN, and the expression rate of CD62L was significantly lower in patients with tuberculosis and normal controls (P0.05). Conclusion CD62L on PMN surface of patients with tuberculosis is involved in the chemotactic process of PMN, plays an important role in the reaction of tuberculosis, and promotes the development of tuberculosis.
【作者单位】： 蚌埠医学院病理生理学教研室;感染与免疫安徽省重点实验室;
【基金】：国家科技重大专项基金课题(No.2008ZX10003011) 高等学校优秀青年人才基金项目(No.2012SQRL098) 安徽省高等学校省级自然科学研究项目(No.kj2012z52) 安徽省重点实验室、工程中心(蚌埠医学院)开放课题(BYKL1406ZD)
【分类号】：R52
本文编号：2497198
[Abstract]:Objective To detect the expression of L-selectin (CD62L) in the peripheral blood of patients with tuberculosis (PM62L) and to explore the role of CD62L in the development of tuberculosis. Methods The expression of CD62L in PMN was detected by flow cytometry, and the expression rate of CD62L in normal human PMN was detected. Results The expression of CD62L on PMN surface in patients with tuberculosis was not significantly different from that of normal human PMN, and the expression rate of CD62L was significantly lower in patients with tuberculosis and normal controls (P0.05). Conclusion CD62L on PMN surface of patients with tuberculosis is involved in the chemotactic process of PMN, plays an important role in the reaction of tuberculosis, and promotes the development of tuberculosis.
【作者单位】： 蚌埠医学院病理生理学教研室;感染与免疫安徽省重点实验室;
【基金】：国家科技重大专项基金课题(No.2008ZX10003011) 高等学校优秀青年人才基金项目(No.2012SQRL098) 安徽省高等学校省级自然科学研究项目(No.kj2012z52) 安徽省重点实验室、工程中心(蚌埠医学院)开放课题(BYKL1406ZD)
【分类号】：R52
【共引文献】
相关博士学位论文 前3条
1 施维维;LAMP-2抗体介导中性粒细胞凋亡异常和胞外捕网在ANCA相关性血管炎中的作用及机制研究[D];第三军医大学;2013年
2 王进;中性粒细胞在牛分枝杆菌感染宿主免疫反应中作用机制的研究[D];中国农业大学;2014年
3 汤贤英;中性粒细胞通过促进IL-33成熟而参与类风湿性关节炎发生和进程[D];华中科技大学;2014年
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