吡嗪酰胺化疗对肺结核患者血尿酸水平的影响及苯溴马隆的干预治疗

发布时间：2019-06-13 23:38

【摘要】：目的调查吡嗪酰胺治疗肺结核患者前后血尿酸水平变化,并探讨苯溴马隆治疗对其的影响,为临床用药提供参考。方法随机选取2013—2014年来该院治疗的197例肺结核患者为研究组,84例非结核性呼吸系统疾病患者以及84例正常体检者为对照组,比较三组样本血尿酸水平的差异;观察肺结核患者接受吡嗪酰胺治疗前后血尿酸水平的变化;以及苯溴马隆干预治疗后血尿酸水平的变化。结果三组人群入院时的血尿酸水平差异无统计学意义(χ2=2.53,P=0.280);入院时三组中高尿酸血症发生率差异有统计学意义(χ2=6.415,P=0.041);197例肺结核患者中有10例初始为高尿酸血症患者,对187例正常尿酸水平患者使用吡嗪酰胺治疗后140例(74.87%)患者血尿酸水平超过正常值,治疗前后尿酸水平差异有统计学意义(t=26.65,P0.001);对其中血尿酸持续性增高的31例患者使用苯溴马隆干预后26例(83.87%)血尿酸水平明显降低,两者的差异有统计学意义(t=3.31,P=0.0024)。结论肺结核患者使用吡嗪酰胺抗结核治疗后血尿酸水平增高明显,但不影响多数患者继续治疗。对于持续性增高患者使用苯溴马隆干预可有效控制血尿酸水平。
[Abstract]:Objective to investigate the changes of serum uric acid level in patients with pulmonary tuberculosis treated with pyrazinamide before and after treatment, and to explore the effect of benzomalone treatment on it, so as to provide reference for clinical use. Methods 197 patients with pulmonary tuberculosis treated in our hospital since 2014 were randomly selected as study group, 84 patients with non-tuberculosis respiratory diseases and 84 normal controls as control group, and the changes of serum uric acid level in pulmonary tuberculosis patients before and after pyrazinamide treatment were observed, and the changes of serum uric acid level in patients with pulmonary tuberculosis before and after treatment with pyrazinamide were observed. Results there was no significant difference in serum uric acid level among the three groups at admission (蠂 ~ 2: 2.53, P = 0.280), but there was significant difference in the incidence of hyperuricemia among the three groups at admission (蠂 ~ 2: 6.415, P 鈮，

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