miRNA在哺乳动物性腺发育中的功能

发布时间：2018-01-22 00:59

本文关键词： miRNA 哺乳动物睾丸卵巢精子卵巢癌性腺发育　出处：《草业科学》2017年04期 　论文类型：期刊论文

【摘要】：MicroRNA(miRNA)作为一种内源性的非编码RNA,以影响靶基因表达的方式来调节机体功能。miRNA能调控哺乳动物性腺(睾丸和卵巢)的发育,促进精子与卵母细胞的分化成熟,影响受精卵的发育过程,并可能作为诊断生殖疾病卵巢癌的重要指标。本文对miRNA的生物合成过程,miRNA在哺乳动物性腺发育以及卵巢癌变过程中的调控功能进行了综述,提出该领域主要发展方向是miRNA在哺乳动物性腺发育中的体内功能研究,希望以分子生物学和生物信息学手段,从分子、系统等不同角度阐明单一某种miRNA在哺乳动物性腺发育及卵巢癌变过程中的具体调节机制和信号通路情况。这为研究哺乳动物生殖疾病,选育畜牧生产中优质品种提供了新的思路和途径。
[Abstract]:MicroRNAs miRNAs as an endogenous non-coding RNA. By affecting the expression of target genes, miRNA can regulate the development of mammalian gonads (testis and ovaries), promote the differentiation and maturation of spermatozoa and oocytes, and affect the development of fertilized eggs. It may be an important index for the diagnosis of ovarian cancer of reproductive diseases. This article reviews the regulation of miRNA biosynthesis in mammalian gonadal development and ovarian carcinogenesis. The main development direction of this field is to study the function of miRNA in mammalian gonadal development in vivo. It is hoped that molecular biology and bioinformatics will be used to study the function of miRNA in mammalian gonadal development. The specific regulatory mechanisms and signaling pathways of a single miRNA in mammalian gonadal development and ovarian carcinogenesis were elucidated from different perspectives, which were used to study mammalian reproductive diseases. Breeding of high quality varieties in livestock production provides new ideas and approaches.
【作者单位】：黄淮学院生物与食品工程学院;
【基金】：河南省科技攻关项目“瓜蒌抗肿瘤多糖关键精制技术及药物筛选模型研究”(152102210025)
【分类号】：S814.1
【正文快照】： k錗icroRNA(miRNA)作为近年来新兴的研究热点,是一类内源性的非编码RNA,长21~24个核苷酸,通常与靶mRNA 3′端的非翻译区结合,从而诱导靶mRNA的降解或抑制靶mRNA的表达,它们广泛存在于植物、微生物、线虫、动物和人类的细胞中[1]。1993年人们首次在秀丽新小杆线虫(Caenorhabdit

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