猪圆环病毒2型综合免疫及母源抗体评估研究

发布时间：2018-01-23 09:30

本文关键词： 猪圆环病毒型母源抗体免疫评估　出处：《动物医学进展》2017年12期 　论文类型：期刊论文

【摘要】：猪圆环病毒2型(PCV-2)参与引起的疾病症候群较为复杂,疫苗免疫效果受多种因素的影响。目前,疫苗的实际免疫效果及其对其他疫苗免疫效果的影响尚不十分清楚。针对这一问题,根据PCV-2病原和WH疫苗株特点,项目组设计了1组母猪、4组仔猪的免疫试验,并持续监测了免疫抗体及仔猪母源抗体变化情况,同时评估PCV-2免疫对其他疫苗(猪瘟、高致病性猪繁殖与呼吸综合征和猪O型口蹄疫)免疫效果的影响。结果显示,仔猪一次性免疫,不能达到理想的免疫效果,间隔2周~3周加强免疫,效果较好,保护抗体可持续到105日龄以上。母猪配种前和产仔前两次免疫,至仔猪断奶后,母猪抗体较高,所产仔猪,28日龄母源抗体较高。PCV-2疫苗免疫不影响上述3种疫苗的免疫效果。
[Abstract]:The disease syndrome caused by porcine circovirus type 2 (PCV-2) is complicated, and the immune effect of vaccine is affected by many factors. The actual immune effect of the vaccine and its effect on the immune effect of other vaccines are not very clear. In view of this problem, according to the characteristics of PCV-2 pathogen and WH vaccine strain, the project team designed a group of sows. Four groups of piglets were immunized, and the changes of immune antibodies and maternal antibodies of piglets were continuously monitored, and the effects of PCV-2 immunization on other vaccines (swine fever) were evaluated. The effect of highly pathogenic porcine reproductive and respiratory syndrome and hog type O foot-and-mouth disease (FMD). The results showed that the single immunization of piglets could not achieve the ideal immune effect, and the immunization should be intensified at intervals of 2 weeks and 3 weeks. The results showed that the protective antibody could last for more than 105 days. Sows were immunized twice before breeding and before birth. After weaning, the antibody of sows was higher and the piglets were produced. The immune effect of the above three vaccines was not affected by the 28-day-old maternal antibody high. PCV-2 vaccine immunization.
【作者单位】：大庆市动物疫病预防与控制中心;大庆市畜牧技术推广站;大庆市动物卫生监督所;
【基金】：2014年黑龙江省级领军人才梯队后备带头人资助项目大庆市指导性科技计划项目(zd-2016-031)
【分类号】：S858.28
【正文快照】： 猪圆环病毒2型(PCV-2)是圆环病毒科圆环病毒属成员,是迄今发现的最小动物病毒,也是继猪繁殖与呼吸综合征病毒之后又一影响养猪业发展的重要病毒。PCV-2不但是断奶仔猪多系统衰竭综合征(PMWS)的主要病原,还常与其他病原混合或继发感染,加重病情,造成猪群发病率和死亡率升高[1-2

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