透骨草含药血清与西药联合对产ESBLs E.coli的体外抑菌作用

发布时间：2018-01-25 07:57

  本文关键词： 透骨草含药血清 棋盘法 产ESBLs大肠杆菌 分级抑菌浓度　出处：《中国兽医学报》2017年01期 　论文类型：期刊论文

【摘要】：为了探讨透骨草含药血清与抗菌药联合对产ESBLs大肠杆菌的抑菌作用,采用棋盘法测定透骨草含药血清与抗菌药联合的FIC指数。透骨草含药血清与头孢曲松钠、头孢他啶、头孢噻肟钠、头孢噻呋钠、阿莫西林、阿米卡星、黏杆菌素、磺胺间甲氧嘧啶(SMM)、环丙沙星、诺氟沙星、左旋氧氟沙星、乙酰甲喹、克林沙星、加替沙星、林可霉素、强力霉素、氟苯尼考、阿奇霉素、磷霉素联合作用后的FIC分别为:0.75、1.00、0.28、0.75、2.00、0.75、2.00、2.00、0.26、0.26、0.26、0.50、0.50、1.00、0.50、3.00、0.26、0.38、1.25。结果显示:透骨草含药血清与环丙沙星、诺氟沙星、左旋氧氟沙星、乙酰甲喹、克林沙星、林可霉素、氟苯尼考、阿奇霉素、头孢噻肟钠体外联合作用为协同作用;与头孢曲松钠、加替沙星、阿米卡星、头孢他啶、头孢噻呋钠体外联合作用为相加作用;与阿莫西林、强力霉素、黏杆菌素、磺胺间甲氧嘧啶体外联合作用为拮抗作用;与磷霉素体外联合作用为无关作用。
[Abstract]:In order to study the bacteriostatic effect of the combination of drug serum and antimicrobial agents on ESBLs producing Escherichia coli. The FIC index of the drug serum and antimicrobial agents was determined by chessboard method. The FIC index of the drug serum and ceftriaxone sodium, ceftazidime sodium, cefotaxime sodium, cefotaxime sodium, amoxicillin and amikacin were determined by chessboard method. Myxin, sulfamethoxine, ciprofloxacin, norfloxacin, levofloxacin, acetyl methaquine, clinfloxacin, gatifloxacin, lincomycin, doxycycline, florfenicol, azithromycin. The FIC after combined action of fosfomycin was 0.280.75 (0.28) and 0.75 (2.00), respectively. The FIC of the two groups was 0.260.26, 0.26, 0.26, 0.26, 0.26, 0.26, 0.26, 0.26 and 0.26, respectively. The results showed that the drug serum and ciprofloxacin and norfloxacin were found in 0.26 0.50 ~ 0.50 ~ 1.50 ~ (0.50) ~ 0.50 ~ 0.50 ~ 0.50 ~ 0.26 ~ 0.36 ~ 0.38 ~ 1.25. the results showed that the drug serum and ciprofloxacin and norfloxacin. The synergistic effects of levofloxacin, acetylmethaquine, clinfloxacin, lincomycin, florfenicol, azithromycin and cefotaxime sodium were synergistic in vitro. Combined with ceftriaxone sodium, gatifloxacin, amikacin, ceftazidime, ceftiofuroxime sodium in vitro; Combined with amoxicillin, doxycycline, myxin and sulfamethoxypyrimidine in vitro was antagonistic. The combined action with fosfomycin in vitro is irrelevant.
【作者单位】： 广西大学动物科学技术学院;
【基金】：国家自然科学基金资助项目(31460675) 国家科技支撑计划资助项目(2012BAD25B04) 广西科技攻关项目(0992014-2) 广西自然科学基金青年基金资助项目(2012GXNSFBA053052);广西自然科学基金资助项目(2013GXNSFAA019070) 广西大学动物科学技术学院科研发展基金资助项目(DK201105) 南宁市科技攻关项目(20141295);南宁市科技攻关项目(201102100G)
【分类号】：S859.7
【正文快照】： Antibiotic effects of serum contained Phryma leptostachya L.var.Asiatica Haracombined with antibiotics against ESBLs-producing E.coli in vitroLIU Zeng-yuan,WU Yong-ji,SUN Yan-jie,SONG Jian-wu,HUANG Kai,SI Hong-bin*(College of*Corresponding author,E-mail:，

本文编号：1462408