支原体分泌蛋白研究进展

发布时间：2018-02-24 11:17

本文关键词： 支原体分泌蛋白靶标疫苗致病性免疫　出处：《畜牧兽医学报》2017年09期 　论文类型：期刊论文

【摘要】：支原体是人和动物的重要病原体,因缺乏特效药物和疫苗用于治疗和预防,常造成很大损失。支原体致病与免疫机制不清是阻碍防治手段研发的重要原因。分泌蛋白直接参与病原体与宿主的交流,是病原体发挥致病和免疫作用的重要组分,可望作为药物和疫苗的潜在靶标。然而支原体分泌蛋白研究尚处于初级阶段,已鉴定的支原体分泌蛋白很少,其在致病与免疫中的作用有待研究。笔者介绍了已发现的支原体分泌蛋白、分泌方式以及其研究方法,以期为支原体分泌蛋白相关研究提供参考。
[Abstract]:Mycoplasma is an important pathogen in humans and animals, due to the lack of special drugs and vaccines for treatment and prevention, Mycoplasma is an important factor that hinders the development of prevention and control methods. Secretory proteins are directly involved in the communication between pathogens and hosts, and are important components of pathogens to play a pathogenic and immune role. It is expected to be a potential target for drugs and vaccines. However, the study of mycoplasma secretory proteins is still in its infancy, and the identified mycoplasma secreted proteins are few. The role of mycoplasma in pathogenesis and immunity needs to be studied. This paper introduces the secreting protein, secretion mode and research methods of mycoplasma, in order to provide reference for the study of mycoplasma secretory protein.
【作者单位】：华中农业大学农业微生物学国家重点实验室;华中农业大学动物医学院;
【基金】：国家自然科学基金国际(地区)合作交流项目(3161101352) 国家重点研发计划(2016YFD0500906) 现代农业(肉牛牦牛)产业技术体系专项经费(CARS-38)
【分类号】：S852.62

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