乳脂球膜蛋白的研究进展

发布时间：2018-02-27 16:36

本文关键词： 乳脂球乳脂球膜蛋白研究进展　出处：《中国畜牧兽医》2016年07期 　论文类型：期刊论文

【摘要】：乳脂球膜蛋白是乳腺在泌乳时包被在脂肪滴外的膜蛋白。乳脂肪球膜(milk fat globule membrane,MFGM)是磷脂、鞘脂和多种蛋白质组成的3层膜结构。乳脂球膜蛋白包含100余种蛋白质,含量最丰富的8种蛋白质为黏液素1、黄嘌呤氧化还原酶、黏液素15、CD36、嗜乳脂蛋白、乳凝集素、脂肪分化相关蛋白和脂肪酸结合蛋白。乳脂球膜蛋白已被证明具有丰富的开发利用价值,包括:反映奶牛母体的生理状态;作为幼体的营养和免疫来源,会影响犊牛的发育和母源抗体;会影响人和动物的免疫调节和体质,未来可能应用于疾病的治疗。作者介绍了乳脂球膜蛋白的来源、组成及一种新建立的乳脂球膜蛋白结构,阐述了几个主要蛋白的生理特性及乳脂球膜蛋白的研究进展,并对未来的研究方向提出建议。
[Abstract]:Fat globule membrane membrane protein (MFGM) is a three-layer membrane structure composed of phospholipids, sphingolipid and many proteins. The eight most abundant proteins were myxine 1, xanthine redox enzyme, myxine 15 CD36, milk lipoprotein, lactoagglutinin, Fat differentiation related proteins and fatty acid binding proteins. Milk fat globular membrane proteins have been proved to be of great value in development and utilization, including: reflecting the physiological state of the mother body of dairy cows; as a source of nutrition and immunity for the young. It will affect the development of calves and maternal antibodies, affect the immune regulation and constitution of human and animal, and may be used in the treatment of diseases in the future. The authors introduce the origin, composition and structure of a new type of lactoglobular membrane protein. The physiological characteristics of several main proteins and the research progress of milkfat globular membrane proteins were reviewed, and suggestions for future research were put forward.
【作者单位】：黑龙江八一农垦大学;
【基金】：黑龙江省新世纪人才项目(1252-NCET-003) 国家科技支撑计划(2013BAD21B01) 国家自然科学基金(31272625)
【分类号】：S852.2

【参考文献】