自噬在疯草中毒中的作用及其机制

发布时间：2018-03-09 05:36

本文选题：疯草　切入点：苦马豆素　出处：《中国兽医学报》2017年09期 　论文类型：期刊论文

【摘要】：疯草已成为危害我国西部草原畜牧业发展的主要毒草,其主要有毒成分苦马豆素,能特异性地抑制α-甘露糖苷酶活性造成细胞内异常糖蛋白的形成,异常蛋白的清除主要在溶酶体进行,而溶酶体α-甘露糖苷酶活性被抑制使蛋白质清除受阻,最终出现与α-甘露糖苷贮积症相似的病理变化即广泛的空泡变性。自噬可以将自身受损、变性大分子物质运送到溶酶体进行自我消化,有资料显示,自噬降解受阻会导致自噬体蓄积形成空泡样病变。根据自噬的形成和作用机制,我们推测疯草中毒造成的空泡变性可能与自噬有关。现就从疯草中毒机制、自噬分子机制及疯草中毒与自噬的关系等方面进行综述,以期为苦马豆素毒性及作用机制研究提供理论依据。
[Abstract]:Wild grass has become the main poisonous grass that endangers the development of grassland animal husbandry in the west of China. Its main toxic component, hyacinine, can specifically inhibit the formation of abnormal glycoprotein in cells caused by 伪 -mannosidase activity. The clearance of abnormal proteins is mainly carried out in lysosomes, and the inhibition of lysosomal 伪 -mannosidase activity hinders the clearance of proteins. Eventually, a pathological change similar to that of 伪 -mannoside storage is widespread vacuolar degeneration. Autophagy can damage itself, and the denatured macromolecules are transported to the lysosome for self-digestion. The inhibition of autophagy degradation may lead to vacuolation of autophagy. Based on the mechanism of autophagy, we speculate that the vacuolar degeneration caused by verdant poisoning may be related to autophagy. The mechanism of autophagy and the relationship between poisoning and autophagy were reviewed in order to provide a theoretical basis for the study of the toxicity and mechanism of virulence.
【作者单位】：西北农林科技大学动物医学院;
【基金】：中央高校基本科研业务费科技创新重点资助项目(2452016047) 农业部“十二五”公益性行业(农业)科研专项资助项目(201203062)
【分类号】：S856.9

【相似文献】