磺胺类药物残留检测的研究

发布时间：2018-03-18 11:06

本文选题：磺胺类药物　切入点：残留检测　出处：《上海交通大学》2015年硕士论文　论文类型：学位论文

【摘要】：在畜牧业的生产中,常常需要在饲料中添加一些抗生素以降低家禽及牲畜的发病率,提高出栏率和商品率。其中磺胺类药物因抗菌谱广、使用方便、价格低廉,在实际生产中得到了广泛应用。但是如果使用不当或过度使用,则会引起细菌对于磺胺类药物的耐药性,同时在下游产品中引起残留,危害人体健康。随着2011年的“瘦肉精事件”的影响,人们对食品安全问题越发地重视,磺胺类药物的残留也成为国家重点监控的对象之一。磺胺类药物残留的检测方法也成为大家研究的热点,其中液相色谱法是最为广泛使用的方法之一。而随着色谱填料技术的不断发展,一批新型的色谱填料迅速涌现,极大的方便了磺胺类药物残留快速准确的检测。采用新技术、新方法优化传统方法,可有效提高效率、降低成本,扩大检测范围和检测能力。本文共分五部分,第一部分主要概述了磺胺类药物的基本情况及药物残留的危害及现状,第二部分主要综述了近年来磺胺类药物残留的分析方法研究概况,第三部分采用了新型的壳核型色谱填料开发了快速测定9种磺胺类药物液相方法,第四部分采用了新开发的液相方法对饲料中9种磺胺类药物残留的进行测定并进行方法学研究,第五部分对新技术应用在传统方法上的前景作了展望。
[Abstract]:In the production of animal husbandry, it is often necessary to add some antibiotics to the feed to reduce the morbidity of poultry and livestock, and to increase the rate of production of livestock and livestock, among which sulfonamides are cheap because of their wide antibacterial spectrum, ease of use and low price. It is widely used in actual production. But if it is misused or overused, it can lead to bacterial resistance to sulfanilamides and residues in downstream products. Harm to human health. With the impact of the "lean meatine incident" in 2011, people are paying more and more attention to food safety issues. The residue of sulfanilamides has also become one of the objects of national key monitoring. The detection method of sulfonamide residues has also become a hot research topic. Among them, liquid chromatography is one of the most widely used methods. With the continuous development of chromatographic packing technology, a number of new chromatographic fillers emerge rapidly, which greatly facilitates the rapid and accurate detection of sulfanilamide residues. The new method can effectively improve the efficiency, reduce the cost, expand the detection range and detection ability. The first part summarizes the basic situation of sulfanilamides and the harm and present situation of the drug residues. In the second part, the methods for the analysis of sulfanilamide residues in recent years were reviewed. In the third part, a rapid liquid phase method for the determination of 9 sulfonamides was developed by using a novel shell karyotype chromatographic filler. In part 4th, the newly developed liquid phase method was used to determine the residues of 9 sulfonamides in feed and the methodological study was carried out. In part 5th, the prospect of the application of the new technology in the traditional methods was prospected.
【学位授予单位】：上海交通大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：S859.84

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