2012年～2015年安徽地区猪丹毒的流行特征及病原分离株药物敏感性分析

发布时间：2018-03-29 21:27

本文选题：猪丹毒　切入点：流行特征　出处：《中国预防兽医学报》2017年05期

【摘要】：为了解猪丹毒在安徽地区的流行特征和再发原因以及临床防治的敏感药物,本研究针对2012年~2015年安徽地区发生的猪丹毒进行流行病学调查,对分离菌株进行吖啶黄敏感性试验以及微量肉汤稀释法测定最小抑菌浓度(MIC)。结果显示,在合肥、六安、安庆、蚌埠等地猪丹毒发生率较高,7月~9月为高峰期,主要集中于育肥阶段(61.9%),以急性败血症型为主(92.9%)。42株分离菌株虽对青霉素(PEN)、氨苄青霉素(AMP)、头孢噻肟(CTX)、头孢曲松(CRO)等抗生素的敏感率均高于80%,但耐受5种及以上抗菌药物的比例达95.2%,其中耐庆大霉素(GEN)+卡那霉素(KAN)+链霉素(STR)+克林霉素(CLI)+林肯霉素(LIN)占81%。有4株可以在含0.02%吖啶黄的脑心浸液培养基(BHI)琼脂平板上生长。结果表明,安徽地区猪丹毒呈散发性或地方性流行,多发生于夏秋季节,临床特征多为育肥猪的急性败血症,青霉素类药物仍是防治猪丹毒的首选药物。本研究揭示安徽地区猪丹毒再发原因与弱毒菌苗株可能的毒力返强无关,并为该地区猪丹毒的有效防控提供科学依据。
[Abstract]:In order to understand the epidemic characteristics and recurrence causes of porcine erysipelas in Anhui and the sensitive drugs for clinical prevention and treatment, an epidemiological survey was carried out on porcine erysipelas from 2012 to 2015 in Anhui Province.Acridine yellow sensitivity test and minimal inhibitory concentration (MIC) were determined by broth dilution method.The results showed that the incidence of erysipelas was higher in Hefei, Lu'an, Anqing and Bengbu, and the peak was from July to September.Mainly concentrated in the fattening stage, the susceptibility rate of 42 isolates to penicillin, ampicillin, cefotaxime, ceftriaxone (CRO) and other antibiotics was higher than 80%, but resistant to 5 or more antibiotics was higher than that of 80%, but resistant to 5 or more antibiotics was higher than that of Ceftriaxone (CRO), although the sensitivity of 42 isolates to penicillin, ampicillin, ceftriaxone and so on was higher than that of 80%.The proportion of gentamicin resistant to gentamicin (Gen) kanamycin (kanamycin) streptomycin (STR) clindamycin (CLI) lincomycin (Linn) accounted for 81%.Four strains could grow on the Agar plate containing 0.02% acridine yellow.The results showed that porcine erysipelas were sporadic or endemic in Anhui province, and most of them occurred in summer and autumn seasons. The clinical characteristics were mostly acute septicemia of fattening pigs. Penicillin was still the first choice for prevention and treatment of porcine erysipelas.This study revealed that the recurrence of erysipelas in Anhui had nothing to do with the possible virulence of attenuated strain, and provided scientific basis for the effective prevention and control of erysipelas in this area.
【作者单位】：安徽农业大学动物科技学院;安徽省畜禽产业共性技术研究院;
【基金】：国家星火计划重点项目(2014GA710002) 安徽省质量工程项目(2013sxzx008) 安徽农业大学大学生创新基金项目(XJ2015093) 安徽省生猪产业体系基金
【分类号】：S858.28

【相似文献】