抗氧化剂对精子质量影响的研究进展

发布时间：2018-04-30 02:20

本文选题：精子 + 体外受精　；参考：《中国畜牧杂志》2017年07期

【摘要】：为提高优良公畜的利用率并获得大量高质量的胚胎,畜牧业引入体外授精技术。体外授精技术成功的关键因素之一是精液保存,精液长期保存的方法主要是冷冻保存。然而,冷冻容易使精子受到氧化应激损伤。其中一个原因是体外的精子缺乏机体内氧化-抗氧化体系的保护;另外冷冻会刺激精液产生过量的活性氧(ROS)组分,二者均能削弱精子的抗氧化能力,导致精子的结构和功能受到损伤。ROS是造成氧化应激的关键因素之一,它会影响精子质量,进一步降低胚胎成活率,最终导致动物繁殖能力下降。针对这一问题,科学工作者已研究了大量的改进措施,如添加抗氧化剂、改善精液储存的环境条件,或二者协同处理。目前,抗氧化药物已在体外受精领域取得很大的新突破,但精子受到氧化损伤的问题还未完全解决,本文就目前精子抗氧化方面的研究作一综述。
[Abstract]:In order to improve the utilization rate of good male animals and obtain a large number of high-quality embryos, animal husbandry introduced in vitro insemination technology. One of the key factors for the success of in vitro insemination is semen preservation, and cryopreservation is the main method of long-term semen preservation. However, freezing can easily damage sperm by oxidative stress. One reason is that sperm in vitro lacks the protection of the body's oxidation-antioxidant system, and freezing stimulates semen to produce excessive amounts of reactive oxygen species (Ros), both of which weaken the antioxidant capacity of sperm. Ros is one of the key factors causing oxidative stress, which will affect sperm quality, further reduce embryo survival rate, and ultimately lead to the decline of animal reproductive ability. In response to this problem, scientists have studied a large number of improvement measures, such as adding antioxidants, improving the environmental conditions of semen storage, or the combination of the two. At present, antioxidant drugs have made a great breakthrough in the field of in vitro fertilization, but the problem of sperm oxidative damage has not been completely resolved.
【作者单位】：延边大学农学院畜牧学系;
【基金】：国家自然科学基金项目(31360546)
【分类号】：S814

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