畜禽支原体耐药性及耐药机制研究进展

发布时间：2018-05-30 10:40

本文选题：畜禽 + 支原体　；参考：《中国畜牧兽医》2017年08期

【摘要】：支原体感染给畜禽养殖造成的危害已受到国内外科研人员的广泛重视。目前控制畜禽支原体感染、降低畜禽养殖经济损失的切实有效方法是大量使用抗生素,其中四环素、大环内酯类及喹诺酮类药物是现阶段临床兽医首选的3类抗菌药。但短短几十年的临床实践表明,滥用抗生素已经严重威胁畜禽健康,许多畜禽支原体临床分离株不仅仅对单一抗生素产生耐药性,而且同时对多种抗生素耐药。作者从药物靶位点改变、外排泵系统形成、抗菌药物灭活酶产生等方面对上述抗畜禽支原体药物的耐药机制进行阐述,以期为建立支原体耐药性检测体系、指导临床合理用药、开发新的药物等提供理论依据和策略。
[Abstract]:The harm caused by mycoplasma infection to livestock and poultry breeding has been paid much attention by researchers at home and abroad. At present, the effective and effective way to control the mycoplasma infection and reduce the economic loss of livestock and poultry is the use of antibiotics, of which tetracycline, macrolide and quinolones are the 3 kinds of antibiotics preferred at the present stage of clinical veterinarian. But a few decades of clinical practice have shown that the abuse of antibiotics has seriously threatened the health of livestock and poultry. Many clinical isolates of Mycoplasma mycoplasma are not only resistant to a single antibiotic, but also resistant to a variety of antibiotics. The authors have changed the drug target loci, the outer row pump system and the production of antibacterial inactivation enzymes. The mechanism of resistance to Mycoplasma mycoplasma is described in order to provide theoretical basis and strategy for the establishment of Mycoplasma resistance detection system, to guide clinical rational use of drugs and to develop new drugs.
【作者单位】：中国农业科学院兰州兽医研究所家畜疫病病原生物学国家重点实验室农业部兽医公共卫生重点开放实验室草食动物细菌病创新团队;
【基金】：国家自然科学基金(3602051)
【分类号】：S852.62

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