犬瘟热病毒受体及其跨宿主感染

发布时间：2018-06-03 20:43

本文选题：犬瘟热 + 犬瘟热病毒(CDV)　；参考：《病毒学报》2017年03期

【摘要】：犬瘟热是由犬瘟热病毒(Canine distemper virus,CDV)感染引起的一种高度接触性传染病,其可跨宿主感染不同科属的多种动物并造成较高的死亡率,因此该病对养犬业、经济动物养殖业和野生动物保护业造成了很大危害。近年来,随着生态环境变化及病毒变异,CDV的宿主范围也不断扩大。目前已鉴定的CDV两种受体—SLAM和nectin-4,分别在宿主免疫细胞和上皮细胞上表达,二者与CDV血凝素(H)蛋白的相互作用是决定CDV跨宿主感染和病毒诱导宿主免疫抑制等致病性的基础。本文就近年来国内外对CDV受体及其跨宿主感染研究进展进行了综述。
[Abstract]:Canine distemper is a highly contagious disease caused by canine distemper virus (canine distemper virus) infection. Economic animal breeding and wildlife protection have caused great harm. In recent years, the host range of CDV has been expanded with the change of ecological environment and virus variation. At present, two CDV receptors, -SLAM and nectin-4, are expressed in host immune cells and epithelial cells, respectively. Their interaction with CDV hemagglutinin (CDV) protein is the basis for determining the pathogenicity of CDV cross-host infection and virus-induced host immunosuppression. This article reviews the research progress of CDV receptor and its cross-host infection in recent years.
【作者单位】：中国农业科学院特产研究所;
【基金】：国家自然科学基金青年科学基金(项目号:31502102),题目:犬瘟热病毒变异株对水貂致病性增强的分子机制~~
【分类号】：S852.65

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