新型三嗪类抗球虫药沙咪珠利在鸡体外各组织中的代谢比较

发布时间：2018-06-11 22:43

本文选题：新型抗球虫药 + 组织代谢　；参考：《中国动物传染病学报》2017年04期

【摘要】：沙咪珠利(Ethanamizuril,EZL)是中国农业科学院上海兽医研究所自主研发的一种新型三嗪类抗球虫药。沙咪珠利给鸡灌服后在其体内被代谢为多种代谢产物,其中代谢物M3为主要代谢产物之一。在研究沙咪珠利在鸡各组织中残留消除规律的过程中发现,一定量的沙咪珠利添加到相同重量的肾脏、肝脏以及肌肉组织匀浆中,样品前处理后,通过UPLC方法检测,在肾脏组织几乎未检测到原药沙咪珠利,却意外检测到了代谢物M3,而在其他组织中未见此种现象发生。为了进一步研究此种情况,我们称取等量的肾脏匀浆组织,添加沙咪珠利后于不同时间处理,结果发现孵育20 min后肾脏中几乎检测不到原药;另外,将鸡体肾脏组织高温处理后,再添加沙咪珠利处理,则可以检测到沙咪珠利,研究结果表明原药沙咪珠利主要在肾脏组织中被代谢为M3。该研究结果为进一步研究沙咪珠利在鸡体的代谢途径提供了重要研究基础。
[Abstract]:EZL is a new triazine anticoccidial drug developed by Shanghai Veterinary Research Institute of Chinese Academy of Agricultural Sciences. Salamicarb was metabolized in chicken and M3 was one of the main metabolites. In the course of studying the rule of removing the residue of amitridamole in chicken tissues, it was found that a certain amount of salimide was added to the homogenate of kidney, liver and muscle tissue of the same weight. The sample was pretreated and detected by UPLC method. There was almost no detectable drug amarb in renal tissue, but unexpected detection of metabolite M _ 3, which was not found in other tissues. To further study this condition, we said that the same amount of kidney homogenate tissue was treated at different time after adding amarb. It was found that there was almost no original drug in the kidney after 20 min incubation. When the kidney tissue of chicken was treated with high temperature and then treated with amitridamole, the results showed that the original drug was metabolized as M3 in kidney tissue. The results provide an important basis for further study on the metabolic pathway of amitridamole in chicken body.
【作者单位】：中国农业科学院上海兽医研究所;
【基金】：新型动物专用药物的研制与应用(201303038) 中国农业科学院上海兽医研究所中央级公益性科研院所基本科研业务费专项资金项目(2016PT44;2016JB04)
【分类号】：S859.795

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