乳酸菌和酵母菌混合发酵脱毒橡胶籽的安全性试验研究

发布时间：2018-06-17 10:59

本文选题：融合魏斯菌 + 库德里阿兹威毕赤酵母　；参考：《扬州大学学报(农业与生命科学版)》2017年03期

【摘要】：选昆明小鼠130只,雌雄各半,随机分为13组,每组10只。7d灌胃急性毒性试验和30d灌胃慢性毒性试验各5组,30d饲喂试验3组,通过灌胃的给药方式测量每组小鼠的体重和脏器比,以验证融合魏斯菌(Weissella confusa)CMR-1与库德里阿兹威毕赤酵母(Pichia kudriavzevii)JM-2的安全性以及评估混合发酵脱毒橡胶籽的安全性。结果表明:在7d急性毒性试验及30d慢性毒性试验中,灌胃CMR-1、JM-2与对照组小鼠相比均无显著差异;在30d饲喂试验中,饲喂脱毒橡胶籽的小鼠与对照组相比无显著差异。饲喂未发酵脱毒橡胶籽的小鼠与对照组相比,心体比、肝体比出现极显著差异,脾体比、肺体比、肾体比无显著性差异。
[Abstract]:130 Kunming mice, half male and half male, were randomly divided into 13 groups, 10 rats in each group were given acute toxicity test for 7 d and 5 groups were fed with chronic toxicity test for 30 days. The body weight and organ ratio of each group were measured by oral administration. To verify the safety of the fusion of Weiss strain Weissella confusagne CMR-1 and Pichia kudriavzevii JM-2 and to evaluate the safety of mixed fermentation of detoxified rubber seeds. The results showed that there was no significant difference in acute toxicity test at 7 days and chronic toxicity test in 30 days, but there was no significant difference between mice fed with detoxified rubber seed and control group. Compared with the control group, the ratio of heart to body, liver and body of mice fed with unfermented detoxified rubber seeds showed very significant difference, but the ratio of spleen to body, lung to body and kidney to body had no significant difference.
【作者单位】：昆明理工大学生命科学与技术学院;昆明益口福生物技术有限公司;
【基金】：国家自然科学基金应急管理项目(31640079)
【分类号】：S816

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