抗菌肽在猪生产中的应用研究

发布时间：2018-06-25 23:40

本文选题：抗菌肽 + 猪生产　；参考：《广西大学》2017年硕士论文

【摘要】：针对养殖场长期使用甚至滥用抗生素的严重现象,研发新产品替代抗生素已迫在眉睫。抗菌肽因抗菌谱广、无耐药、无残留,还能提高机体免疫力等优点,在养殖畜牧业具有广阔的应用前景。本文旨在将抗菌肽和传统抗菌药进行比较,特别是在猪生产上的应用,分析抗菌肽应用中的优势与作用特点并对其前景进行展望;探究抗菌肽在猪生产中应用的可行性,比较在母猪妊娠后期和断奶仔猪日粮中添加不同剂量抗菌肽所产生的效果,寻求这两个生产阶段应用抗菌肽的最佳剂量,我们进行了本次实验。本实验分别在妊娠后期母猪日粮基础上添加3%、5%的抗菌肽,与饲喂基础日粮的对照A组一起进行为期40天的饲养试验,观察比较试验期间三组母猪的便秘情况、繁殖性能等;在仔猪达30日龄时进行断奶,再分别在对应仔猪日粮中添加3%、5%的抗菌肽,与饲喂基础日粮的对照B组一起进行为期30天的饲养试验,观察比较三组断奶仔猪的生长性能、腹泻情况、抵抗力、经济效益等。结果表明,抗菌肽可减少母猪在妊娠后期便秘的发生率,但效果不显著(P0.05);可显著增加仔猪出生重、平均产活仔数、平均产健仔数和健仔率(P0.05),但添加量在3%与5%时对仔猪以上参数无显著性差异(P0.05);唯独添加3%抗菌肽时可显著提高母猪产仔数(P0.05),添加5%抗菌肽时对母猪产仔数无明显差异(P0.05)。抗菌肽可显著提高断奶仔猪体重和日增重(P0.05),显著降低动物的日采食量和料肉比(P0.05),但抗菌肽添加量在3%与5%时对断奶仔猪的体重无显著性差异(P0.05);无论抗菌肽添加量在3%、5%时,仔猪血清中抗体阳性率均比对照组高,差异显著(P0.05);经计算日粮中添加抗菌肽还可以显著提高养殖经济效益(P0.05)。这些实验结果为在猪生产中科学使用抗菌肽提供有力依据。
[Abstract]:In view of the serious phenomenon of long-term use and even abuse of antibiotics in livestock farms, it is urgent to develop new products instead of antibiotics. Because of its wide antibacterial spectrum, no drug resistance, no residue, and so on, antimicrobial peptides can improve the immunity of the body, so it has a broad application prospect in raising animal husbandry. The purpose of this paper is to compare antibacterial peptides with traditional antimicrobial drugs, especially in pig production, to analyze the advantages and characteristics of antimicrobial peptide application and to prospect its future, and to explore the feasibility of the application of antimicrobial peptide in pig production. To compare the effects of different doses of antimicrobial peptides in the diets of sows in late pregnancy and weaning, and to find out the best dosage of antimicrobial peptides in these two stages of production, we conducted this experiment. In this experiment, we added 3 5% antimicrobial peptides to the diet of later pregnant sows, and carried out the feeding experiment for 40 days together with the control group A which was fed the basal diet. The constipation and reproductive performance of the three groups were observed and compared during the trial. After weaning at 30 days of age, the piglets were fed with 3 5% antimicrobial peptides in the diets of the corresponding piglets for 30 days. The growth performance of the weaned piglets was observed and compared with that of the control group B, which was fed the basal diet for 30 days. Diarrhea, resistance, economic benefits, etc. The results showed that antimicrobial peptide could reduce the incidence of constipation in sows in late pregnancy, but the effect was not significant (P0.05), and significantly increased the birth weight of piglets and the average number of live piglets. Average healthy litter size and healthy litter rate (P0.05), but the addition of 3% and 5% had no significant difference in piglets above the parameters (P0.05), only when the addition of 3% antimicrobial peptide significantly increased the litter size of sows (P0.05), the addition of 5% antimicrobial peptide had no significant difference in litter size (P0.05). Antimicrobial peptide significantly increased the body weight and daily gain of weaned piglets (P0.05), significantly decreased the daily feed intake and feed / meat ratio (P0.05), but there was no significant difference in the body weight of weaned piglets between 3% and 5% (P0.05). The positive rate of antibody in serum of piglets was higher than that of the control group (P0.05), and the economic benefit of culture could be improved significantly by adding antimicrobial peptides to the diet (P0.05). These results provide a strong basis for the scientific use of antimicrobial peptides in pig production.
【学位授予单位】：广西大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：S828.5

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