氟苯尼考对三种猪呼吸道病原菌标准株的体外抗菌类型研究

发布时间：2018-06-29 05:40

本文选题：氟苯尼考 + 猪呼吸道病原菌　；参考：《新疆农业科学》2017年03期

【摘要】：【目的】研究氟苯尼考对常见猪呼吸道病原菌的抗菌类型。【方法】对猪链球菌、猪胸膜肺炎杆菌及多杀性巴氏杆菌标准株进行最低抑菌浓度(MIC)、最小杀菌浓度(MBC)、抗菌后效应(PAE)的测定和体外杀菌曲线的绘制。【结果】氟苯尼考对上述病原菌的MIC和MBC依次为0.25~0.5μg/m L和2~4μg/m L,PAE结果显示,氟苯尼考对3株病原菌均随暴露浓度的增大和时间的延长其抗菌后效应明显延长;体外杀菌曲线表明,氟苯尼考对上述三株病原菌均有很好的抗菌能力,且抗菌效应随药物浓度的增大而明显增强。【结论】氟苯尼考对常见猪呼吸道病原菌的抗菌类型为浓度依赖型。
[Abstract]:[objective] to study the antimicrobial types of florfenicol against common pathogens of swine respiratory tract. [methods] Streptococcus suis, The minimal inhibitory concentration (MIC), minimal bactericidal concentration (MBC), post-antibacterial effect (PAE) and in vitro bactericidal curve of standard strains of Pneumonibacterium pleuropneumoniae and Pasteurella multocida were determined. [results] MIC of florfenicol against these pathogens was determined. And MBC were 0.25 渭 g / mL and 2 渭 g / mL, respectively. The bactericidal effect of florfenicol on the three pathogens was obviously prolonged with the increase of exposure concentration and time, and the bactericidal curve in vitro showed that florfenicol had a good antibacterial ability against the three pathogens. The antimicrobial effect of florfenicol was obviously increased with the increase of drug concentration. [conclusion] the antimicrobial effect of florfenicol against common pathogenic bacteria in swine respiratory tract was concentration-dependent.
【作者单位】：塔里木大学动物科学学院/新疆生产建设兵团塔里木畜禽科技重点实验室;
【基金】：国家自然科学基金“氟苯尼考对猪链球菌的药动学-药效学同步模型研究”(31660729) 塔里木大学校长基金-青年创新资金项目“氟苯尼考包合物微球纳米混悬剂的制备”(TDZKQN201603)~~
【分类号】：S858.28

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