抗菌肽CJH对LPS免疫应激仔猪血液生理生化指标的影响

发布时间：2018-07-22 20:53

【摘要】：为了研究抗菌肽CJH在细菌性感染导致的仔猪免疫应激方面的应用效果,试验利用大肠杆菌脂多糖(LPS)成分建立了仔猪免疫应激模型,通过比较分析抗菌肽CJH对仔猪血液生理生化指标的影响,探明其在仔猪免疫应激方面的作用。结果表明:LPS组白细胞(WBC)、中性粒细胞(NEUT)数量显著提高(P0.05),红细胞(RBC)、血小板(PLT)、淋巴细胞(LMY)和单核细胞(MUNU)的数量显著降低(P0.05),同时谷氨酰转肽酶(GGT)、天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、碱性磷酸酶(ALP)、乳酸脱氢酶(LDH)、总胆汁酸(TBA)、肌酸激酶(CK)、皮质醇(PCL)、尿素氮(BUN)和肌酐(CREA)的水平显著提高(P0.05),总蛋白(TP)、球蛋白(GLB)及高密度脂蛋白胆固醇(HDL-C)的水平显著降低(P0.05);而抗菌肽CJH+LPS组在不同程度上改善了上述情况,说明抗菌肽CJH对于LPS导致的仔猪免疫应激症状具有明显的改善效果。
[Abstract]:In order to study the effect of antimicrobial peptide CJH on immune stress of piglets caused by bacterial infection, the immune stress model of piglets was established by using lipopolysaccharide (LPS) of Escherichia coli. The effects of antimicrobial peptide CJH on blood physiological and biochemical indexes of piglets were compared and its role in immunological stress of piglets was investigated. The results showed that the number of WBC, neut, erythrocyte (RBC), platelet (PLT), lymphocyte (LMY) and monocyte (MUNU) decreased significantly (P0.05), while glutamyl transpeptidase (GGT), aspartate aminotransferase (AST), glutamyl transpeptidase (GGT), aspartate aminotransferase (AST) were significantly decreased in the WBC group (P0.05). Levels of alanine aminotransferase (alt), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), total bile acid (TBA), creatine kinase (CK), cortisol (PCL), urea nitrogen (bun) and creatinine (CREA) were significantly increased (P0.05), total protein (TP), globulin (GLB) and high density lipoprotein cholesterol (HDL-C). The level of CJH decreased significantly (P0.05), and the CJH LPS group improved the above condition to some extent. The results showed that CJH could improve the immune stress symptoms of piglets induced by LPS.
【作者单位】：海南大学农学院;海南省热带动物繁育与疫病研究重点实验室;
【基金】：海南省自然科学基金项目(20163066)
【分类号】：S828

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