猪繁殖与呼吸综合征病毒及其病毒样颗粒疫苗的研究进展

发布时间：2018-09-07 21:48

【摘要】：自北美地区出现猪繁殖与呼吸综合征(PRRS)以来,此病已有几十年的历史,给养猪业带来了毁灭性的打击。感染此病后呼吸系统症状增加,主要侵袭肺部,病变明显而且继发其他病毒和细菌性疾病;怀孕母猪会产生繁殖障碍,导致流产,产死胎和木乃伊胎等。迄今为止临床上仍然使用灭活疫苗和弱毒疫苗来预防此病,但是这两种疫苗都有不可调和的缺陷,并不能提供完全保护力。新型基因工程疫苗病毒样颗粒(VLPs)疫苗是目前的研究热点,因其不具有感染性病毒的遗传物质,仅含有病毒的几种主要结构蛋白,不会造成感染,安全系数高,免疫效果好而被普遍接受。但是猪繁殖与呼吸综合征病毒的VLPs疫苗仍处于实验室开发阶段,不过已经给各类疾病疫苗的研发提供了一个新的思路。文章对猪繁殖与呼吸综合征及其病毒样颗粒疫苗进行综述。
[Abstract]:Swine reproductive and respiratory syndrome (PRRS) has been developing in North America for decades, which has dealt a devastating blow to pig industry. After infection with this disease, the respiratory system symptoms increase, mainly invading the lungs, the lesions are obvious and secondary to other viruses and bacterial diseases; pregnant sows will produce reproductive barriers, resulting in abortion, stillbirth and mummies, etc. So far, inactivated and attenuated vaccines are still used to prevent the disease, but both vaccines have irreconcilable defects and do not provide full protection. New genetic engineering vaccine virus-like particle (VLPs) vaccine is a hot research topic at present. Because it has no genetic material of infectious virus and contains only several major structural proteins of the virus, it will not cause infection and has a high safety factor. The immune effect is good and is generally accepted. However, the VLPs vaccine of porcine reproductive and respiratory syndrome virus is still in the laboratory development stage, but has provided a new idea for the development of various disease vaccines. This article reviews porcine reproductive and respiratory syndrome (RRS) and its virus-like granulocyte vaccine.
【作者单位】：中国农业科学院兰州兽医研究所家畜疫病病原生物学国家重点实验室/OIE/中国国家口蹄疫参考实验室;
【基金】：国家国际合作项目(2012DFG31890) 国家自然科学基金项目(31072143)
【分类号】：S858.28

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